摘要
Abstract
Objective To investigate the clinical value of combined detection of anti-cyclic citrullinated peptide (antiCCP) antibodies,anti-mutated citrullinated vimentin (anti-MCV) antibodies and rheumatoid factor (RF) in rheumatoid arthritis (RA) diagnosis.Methods Anti-CCP,anti-MCV antibodies and RF were detected by ELISA in 101 RA patients(RA group),55 patients with other rheumatic diseases (non-RA group),and 55 healthy controls (control group).The differences of anti-CCP,anti-MCV antibodies and RF in the three groups were compared.Results The positive ratios of anti-CCP,anti-MCV antibodies and RF were significantly higher in the RA group than those in the non-RA group and control group (P ＜ 0.01).In the RA group,the sensitivity of anti-CCP antibodies was 83.2％ with 93.6％ specificity,the sensitivity of anti-MCV antibodies was 70.3％ and the specificity was 94.5％,the sensitivity of RF was 79.2％ with 75.4％ specificity.The specificity of combined detection of anti-CCP,anti-MCV antibodies and RF was increased to 99.1％,with a lower 67.3％ sensitivity.Conclusions The combined detection of anti-CCP,anti-MCV antibodies and RF could improve the diagnostic accuracy of rheumatoid arthritis (RA).关键词
类风湿关节炎/抗环瓜氨酸肽抗体/抗突变型瓜氨酸波形蛋白抗体/类风湿因子Key words
rheumatoid arthritis/ anti-cyclic citrullinated peptide antibodies/ anti-mutated citrullinated vimentin antibodies / rheumatoid factor分类
医药卫生
