实验动物与比较医学2013，Vol.33Issue(3)：180-184,5.DOI:10.3969/j.issn.1674-5817.2013.03.003
流感病毒气溶胶感染小鼠模型的初步研究
Preliminary Research on Mouse Model of Influenza Virus by Aerosol Infection
摘要
Abstract
Objective Preliminary study on the model of influenza which was established by simulation of human natural infection in mouse.Methods ICR mice were infected with H1N1 FM1 and H1N1 PR8 virus by aerosol inhalation.The symptoms and body weight of mice were observed everyday.At 5,12,21 day after infection,the mice were sacrificed.The lungs of mice were weighed,then were done virus assay and pathological observation.Results The clinical symptoms of infection mice were obvious,the body weight lost seriously,lung index increased and pathological changes significantly in the early mid-term,for example the typical pulmonary edema,pulmonary interstitial disease,inflammation and pulmonary congestion appeared in the lung of mice.The influenza virus also can be detected in the early stage.The symptoms of mice getting better,the virus were not detected in the late.Conclusions The established infection mouse model of the influenza virus aerosol by aerosol inhalation is feasible.关键词
气溶胶/流感病毒/小鼠/模型Key words
Aerosol/ Influenza virus/ Mouse/ Model分类
医药卫生引用本文复制引用
杨玉琴,朱召芹,徐春华,何静,彭秀华,周晓辉,胡芸文,周文江..流感病毒气溶胶感染小鼠模型的初步研究[J].实验动物与比较医学,2013,33(3):180-184,5.基金项目
上海市科委资助项目(12140903100) （12140903100）
