世界中医药2013，Vol.8Issue(5)：546-548,3.DOI:10.3969/j.issn.1673-7202.2013.05.024
芍药舒筋片对大鼠膝骨关节炎软骨病理、细胞因子及PⅡCP水平的影响
Effect of Shaoyao Shujin Tablet on Cartilage Pathology, Cytokines and the Level of PⅡCP of Rat Model with Knee Osteoarthritis
摘要
Abstract
Objective: To explore the effect of Shaoyao Shujin tablet on the cartilage pathology , PGE2, TNF-α and the level of P ⅡCP of the rat with knee joint inflammation. Methods:Sixty SD rats were divided into the 6 groups; fake surgery group, model group, control group, high-dose test group, mid-dose test group and the low-dose test group. The Anterior Cruciate Ligament Transection , ACLT were given to rats in the latter 5 groups to establish knee osteoarthritis model. Abdominal aortic blood was separated and the surgery side of the knee was taken after 4 weeks of drug administration. The serum with PGE2, TNF-α and PⅡ CP were checked out after separation. Results ; The morphological changes of articular cartilage under optical microscope indicated that the model was successful . The concentration of PGE2 and PⅡ CP showed statistically significant differences between the test groups and the model group . And the concentration of TNF-α in the test groups had a decreasing trend compared with that in the model group . Conclusion: Shaoyao Shujin tablet can be anti-inflammatory, delay the degeneration of the knee osteoarthritis articular cartilage and so as to protect the articular cartilage .关键词
膝骨关节炎/中医药疗法/@芍药舒筋片/PGE2/TNF-α/PⅡCPKey words
Shaoyao Shujin tablet/ Knee Osteoarthritis/ PGE2/ TNF-α/ PⅡ CP引用本文复制引用
钱春美,袁秀荣,文小平,庞 坚,陈 博..芍药舒筋片对大鼠膝骨关节炎软骨病理、细胞因子及PⅡCP水平的影响[J].世界中医药,2013,8(5):546-548,3.基金项目
上海市卫生局项目(编号:2011XY008) （编号:2011XY008）
