世界中医药2013，Vol.8Issue(5)：557-560,4.DOI:10.3969/j.issn.1673-7202.2013.05.028
胃内漂浮缓释制剂在复方左金和元胡止痛片中的应用研究
Application of Gastric Floating Sustained release Tablets in Chinese Herbal Compound Zuojin and Yuanhuzhitong
谭镭 1詹雁 2阮佳 2徐超群2
作者信息
- 1. 四川大学华西药学院,成都,610041
- 2. 四川省中医药科学院,成都,610041
- 折叠
摘要
Abstract
Objective: To prepare gastric floating sustained release tablets of Chinese herbal compound Zuo jin and Yuanhuzhitong and evaluate its release characteristics in vitro. Methods: The sustained release tablets were prepared with hydroxypropyl methyl cellulose ( HPMC) as hydrophilic gel-matrix and sodium bicarbonate as the foaming agent. The best formulation and preparation routes of the tab -lets were optimized by orthogonal experiment design using floating capability and release profile in vitro as indicators . Results: The investigation showed that the floating sustained -release tablets could quickly emerge on the artificial gastric fluid surface and maintained a sus - tained floating state for over 10 hours in vitro. The sustained release property was good in vitro and the release profiles kept well with the equation of Peppas. Conclusion: The optimized tablets possess quick floating and ideal sustained release characteristics in vitro.关键词
左金/元胡止痛/漂浮/缓释/体外释放Key words
Chinese herbal compound zuojin / Yuanhuzhitong/ Floating/ Sustained-elease/ Release property in vitro 引用本文复制引用
谭镭,詹雁,阮佳,徐超群..胃内漂浮缓释制剂在复方左金和元胡止痛片中的应用研究[J].世界中医药,2013,8(5):557-560,4.
