摘要
Abstract
Objective To study the feature and significance of expression Hepcidin (Hep) ,Hemojuvelin(HJV),Ferroportin (FPN) and transferring-receptor 2(TFR2) in patients with Iron deficiency anemia(IDA). Methods To test the serum levels of Hep,HJV,FPN,TFR2,Erytrhopoeitein (EPO) and serum ferrin (SF) in 28 patients with IDA by with ELISA. Results ①The serum levels of Hep in patients with IDA were 2. 04 ± 1. 27 ng/ml,which were lower than 3. 07 ± 1. 68 ng/ml in control group (t=2. 203 6,P<0. 05). ②The serum levels of HJV in patients with IDA were 0. 65 ± 0. 51 ng/ml,which were lower than 0. 99 ± 0. 46 ng/ml than in control group (t=2. 352 9, P<0. 05). ③The serum levels of TFR2 in patients with in IDA were 8. 15 ± 3. 09 ng/ml,which were higher than 6. 62 ± 1. 42 ng/ml in control group (t=2. 061 7,P<0. 05). ④The serum levels of FPN in patients with IDA were 2. 69 ± 1. 71 ng/ml,which were no statistic differency than 2. 11 ± 0. 58 ng/ ml in control group (P>0. 05). ⑤There were negative correlation between Epo and SF (r= - 0. 495 8, t= 2. 911 0, P< 0. 1),there were positive correlation between Epo and Hep and HJV (r=0. 501 5, t=2. 956 0,P<0. 01; r=0. 515 7,t= 3. 069 l,P<0. 01). ⑥There were positive correlation both the serum levels of Hep and HJV (r=0. 3983, t= 2. 214 1, P< 0. 05). Conclusion In patients with IDA, the expression of TFR2 were higher, but the expression were lower of Hep and HJV. The expression of TFR2,HJV and Hep would be very significance for the anemia development in patients with IDA.关键词
缺铁性贫血(IDA)/铁调素(Hepcidin)/铁幼素(HJV)/膜铁转运蛋白(FPN)/转铁蛋白受体2(TFR2)Key words
iron deficiency anemian (IDA) / hepcidin ( Hep)/ hemojuvelin ( HJV)/ transferrin-receptor 2 ( TFR2 ) / ferropotin (FPN) ,erythropoeitin(EPO) /serum ferrin(SF)分类
医药卫生
