现代检验医学杂志2013，Vol.28Issue(3)：68-72,5.DOI:10.3969/j.issn.1671-7414.2013.03.021
慢性阻塞性肺病患者血清N末端脑钠肽前体的变化及意义
Plasma N-terminal Pro-brain Natriuretic Peptide:A Prognostic Marker in Patients with Chronic Obstructive Pulmonary Disease
摘要
Abstract
Objective To investigate the serum NT-proBNP levels in patients with chronic obstructive pulmonary disease (COPD) and evaluate the clinical significance for the determination of serum NT-proBNP levels. Methods The NT-proBNP and PaO2 ,PaCO2 levels in 37 patients with upper respiratory tract infection,39 patients with chronic bronchitis and 70 patients with COPD,were determined by electrochemiluminescence immunoassay and three-electrode method,respectively. According to the diagnostic criteria of Chinese Society of Respiratory Diseases Society,70 COPD patients were divided into two groups:55 cases of AECOPD and 15 cases of stable COPD. Results Compared with the control group [26. 10(16. 30～ 51. 98)pmol/L] ,the levels of serum NT-proBNP were significantly increased in patients with upper respiratory tract infection group [52.30(25.39 ～ 138.50) pmol/L], chronic bronchitis [203.10(174.40 ～ 439.40) pmol/L] and COPD [277.40 (127. 25 ～ 775. 43) pmol/L] (P< 0. 01). The levels of plasma NT-proBNP were higher in patients with COPD than those with upper respiratory tract infection (P<0. 01). Plasma NT-proBNP levels were significantly increased in patients with a-cute exacerbation of COPD [AECOPD group: 372. 20 (206. 15 ～ 838. 05) pmol/L; stable COPD group: 101. 30 (43. 72 ～ 100. 60)pmol/L, P<0. 05]. Further spearman correlation analysis showed that the NT-proBNP levels were significantly correlated with arterial blood gas parameters such as PaO2(r= -0. 275, P=0. 001) and PaCO2(r=0. 210, P=0. 011). Conclusion Plasma NT-proBNP levels were significantly correlated with the severity of respiratory disease and may be an effective biomarker for the progression of COPD.关键词
血清N末端脑钠肽前体(NT-proBNP)/慢性阻塞性肺病/慢性支气管炎/上呼吸道感染Key words
NT-proBNP/COPD/chronic bronchitis/upper respiratory tract infection分类
医药卫生引用本文复制引用
唐海霞,王苏梦,宋佳希,汪俊军..慢性阻塞性肺病患者血清N末端脑钠肽前体的变化及意义[J].现代检验医学杂志,2013,28(3):68-72,5.基金项目
国家自然科学基金(81271904),南京军区南京总医院青年基金(2012049). （81271904）
