现代检验医学杂志2013，Vol.28Issue(3)：117-120,4.DOI:10.3969/j.issn.1671-7414.2013.03.037
不同生物群解脲脲原体的耐药性差异及临床症状相关性分析
Comparative Analysis of Antibiotic Resistance and Clinical Features between Ureaplasma Urealyticum Biovars
丁进亚 1黄前川 1徐娟 1杨斌 2徐鸣皋1
作者信息
- 1. 广州军区武汉总医院检验科,武汉,430070
- 2. 广州军区武汉总医院皮肤科,武汉,430070
- 折叠
摘要
Abstract
Objective To investigate Ureaplasma urealyticum (Uu) biovars and their relationship between antimicrobial resistance and clinical features. Methods Urethral and cervical swabs of 1 389 patients with nongonococcal urethritis were assayed parallely by drug susceptibility tests of Uu and two Real-time fluorescence quantitative PCR for Uu grouping. Statistical analysis was carried out to determine the characteristics of the distributions of Uu biovars,and to further explore the relationship between Uu biovars and antimicrobial resistance. Results A total of 416 cases were Uu positive out of 1 389 specimens (29. 95%). Among those positive cases,279 (67. 07%) were Parvo biovars,and 137 (32. 93%) were T960 biovars. There was no significant difference in antibiotics resistance (except for azithromycin) between Uu biovars (χ2 =0. 88, P> 0. 05) and just so in their clinical symptoms (χ2 = 2. 00, P>0. 05). The incidence of clinic symptoms in male urethritis by T960 biovar was higher than that with Parvo biovar while their rates detected were almost the same. A higher ratio of that was observed in female patients infected with Parvo biovar compared with T960 biovar (P<0. 05) ,but their symptoms had nothing to do with Uu genotyping. Conclusion Uu genotyping had are benefit with the drug usage in clinic. Uu Parvo biovar was the dominant biovar,and that may be the major pathogens in infections of female genital tract. The two biovars were observed equal rate in male patients while who infected Uu T960 biovar had much more clinic symptoms and syndromes.关键词
解脲脲原体/生物群/耐药性/荧光定量PCR/临床症状Key words
ureaplasma urealyticum/resistance/real-time fluorescence quantitative PCR/biovar/clinical symptoms分类
医药卫生引用本文复制引用
丁进亚,黄前川,徐娟,杨斌,徐鸣皋..不同生物群解脲脲原体的耐药性差异及临床症状相关性分析[J].现代检验医学杂志,2013,28(3):117-120,4.
