实用肝脏病杂志2013，Vol.16Issue(2)：108-110,3.DOI:10.3969/j.issn.1672-5069.2013.02.005
熊去氧胆酸治疗原发性胆汁性肝硬化患者早期应答预测1年疗效
Early prediction of efficacy of ursodeoxycholic acid in the treatment of patients with primary biliary cirrhosis
李红艺 1杨梦晗 1孟霄 1佟小非 1孙亚朦 1赵文珊 1杨爱婷 1马红 1贾继东1
作者信息
- 1. 100050北京市 首都医科大学附属北京友谊医院肝病中心
- 折叠
摘要
Abstract
Objective To early predict the efficacy of ursodeoxycholic acid (UDCA)in the treatment of patients with primary biliary cirrhosis (PBC).Methods Twenty-six patients with PBC were treated with UDCA at dose of 13～15mg.kg-1.d-1 for one year and the response at month three was retrospectively analyzed for the prediction of one-year efficacy.The serum ALP decrease greater than 40％ acted as response.Results At the end of 1 year observation,the response rates were 35％ in 3,35％ in 6,54％ in 9 and 58％ in 12 months;the ROC curve showed 3-month response (0.83,P=0.004,95％C1 0.66～1.01)predicted the 1-year efficacy well,and the Bland-Altman showed 3-month response was consistent with one-year's;there was no significant difference between 3-month responders and the non-responders as respect to age and blood biochemical parameters at baseline.Conclusion 3-month response can predict the efficacy of 1 year in patients with PBC receiving UDCA therapy.关键词
原发性胆汁性肝硬化/熊去氧胆酸/治疗/疗效预测Key words
Primary biliary cirrhosis/ Ursodeoxycholic acid / Therapy / Prediction引用本文复制引用
李红艺,杨梦晗,孟霄,佟小非,孙亚朦,赵文珊,杨爱婷,马红,贾继东..熊去氧胆酸治疗原发性胆汁性肝硬化患者早期应答预测1年疗效[J].实用肝脏病杂志,2013,16(2):108-110,3.
