实用肝脏病杂志2013，Vol.16Issue(2)：116-118,3.DOI:10.3969/j.issn.1672-5069.2013.02.008
自体骨髓干细胞移植治疗失代偿期乙型肝炎肝硬化临床观察
Clinical efficacy of autologous bone marrow stem cell transplantation in treatment of hepatitis B patients with decompensated liver cirrhosis
摘要
Abstract
Objective To evaluate the clinical efficacy and safety of intrahepatic transplantation of autologous bone marrow stem cell (BMSC)in treatment of hepatitis B patients with decompensated liver cirrhosis.Methods 67hospitalized hepatitis B patients with decompensated liver cirrhosis in our department were randomly divided into two groups.There were 33 patients in the transplantation group,and 34 patients in the control group.65～95ml of bone marrow were obtained from patients in transplantation group,and BMSCs were purified and cultured in vitro and 3.0 × 106～5.0 × 106 cells were harvested into l0ml cell suspension,then the cells were injected into the liver through the hepatic artery.The laboratory parameters,clinical symptoms and adverse reactions were observed respectively at week 4,12 and 24 after transplantation.Results At 12th week after transplantation,serum ALT levels in transplantation and control groups were 41.8±17.9U/L and 43.6±21.8U/L (P＞0.05),respectively,total bilirubin were 23.2±9.51μmol/L and 27.5±13.2μmol/L (P＜0.05),ALB were 27.3±6.7g/L and 26.8±6.8g/L,PTA were 44.3％±9.4％ and 37.5％±6.9％(P＜0.05),CHE were 3018±243U/L and 2098±431U/L (P＜0.05);at 24th week,serum ALT levels in the two group were 2.2±12.1U/L and 35.6±18.2U/L,TBIL were 20.9±8.8μmol/L and 24.9±10.7μmol/L (P＜0.05),ALB were 29.2±6.3g/L and 28.9±7.5g/L,PTA were 48.2％±6.7％ and 46.2％±7.8％,CHE were 5012±213U/L and 4089±278U/L (P＜0.05);at 24th week,the Child-Pugh and MELD scores in the transplantation group were 7.9±4.5 and 24.0±8.9,respectively,much lower than in control (8.2±3.6 and 27.0±10.7,P＜0.05).Conclusion The autologous bone marrow stem cell transplantation in hepatitis B patients with decompensated liver cirrhosis is effective and safe.关键词
乙型肝炎/肝硬化/自体骨髓干细胞/移植Key words
Decompensated liver cirrhosis/ Autologous bone marrow stem cell/Transplantation引用本文复制引用
陈阳述,欧阳石,程涛,刘树人,李灼亮,孔祥平,周赤龙..自体骨髓干细胞移植治疗失代偿期乙型肝炎肝硬化临床观察[J].实用肝脏病杂志,2013,16(2):116-118,3.基金项目
总后勤部卫生部科研专项(08BJZ07) （08BJZ07）
