实用肝脏病杂志2013，Vol.16Issue(2)：128-130,3.DOI:10.3969/j.issn.1672-5069.2013.02.012
干扰素治疗慢性乙型肝炎出现HBsAg/抗-HBs血清转换后病情复发
Serum HBsAg re-positive in patients with chronic hepatitis B after hepatitis B surface antigen seroconversion responsive to interferon-α therapy
摘要
Abstract
Objective To investigate the possible factors influencing serum HBsAg re-positivity in patients with chronic hepatitis B after hepatitis B surface antigen seroconversion responsive to interferon-α therapy.Methods The clinical manifestations,liver function tests,HBV DNA and HBeAg in 5 patients with chronic hepatitis B were observed during interferon-α treatment.Results The interferon regimen lasted for 3 to 15 months in this five patients,and the serum HBsAg clearance occurred in 3 to 18 months post-treatment;serum HBeAg positive to negative without HBeAg/anti-HBe seroconversion in three patients just before or at the same time HBsAg lost;serum HBsAb positive continued 6 to 18 months in this five cases,with the recurrence of HBsAg positive as anti-HBs disappeared;one patient had HBV DNA positive (3.36×l06copies/ml) and ALT increased (98u/L)after 30months of therapy who switched to telbivudine treatment;vitiligo occurred in one patient.Conclusion The recurrence of HBsAg after HBsAg/anti-HBs seroconversion in interferon-treated patients with chronic hepatitis B might be related to HBeAg positive,inappropriate discontinuation of interferon therapy and existence of intrahepatic HBV cccDNA.关键词
慢性乙型肝炎/干扰素/HBsAg/血清转换/复发Key words
Hepatitis B / Interferon-α / Hepatitis B surface antigen / Seroconversion/ Relapse引用本文复制引用
张黄醒,张振华,张礼周,袁敏,张亚飞,苏倩,李旭,尹华发..干扰素治疗慢性乙型肝炎出现HBsAg/抗-HBs血清转换后病情复发[J].实用肝脏病杂志,2013,16(2):128-130,3.基金项目
国家重大基础研究计划(973)项目(2009CB526411) （973）
高等学校博士学科点专项科研基金(20093420120005) （20093420120005）
