实用医学杂志2013，Vol.29Issue(11)：1754-1756,3.DOI:10.3969/j.issn.1006-5725.2013.11.014
肢体远隔缺血预处理对胸腔镜体外循环心脏手术的肺保护作用
Pulmonary protective effect of limb remote ischemic preconditioning in thoracoscopic cardiac surgery
摘要
Abstract
Objective To investigate the effect and mechanism of limb remote ischemic preconditioning on pulmonary protection in thoracoscopic cardiac surgery with cardiopulmonary bypass (CPB). Methods Eighty-one patients undergoing thoracoscopic cardiac surgery with CPB , and ASA Ⅱ~Ⅲ , were randomized into experimental group (with limb remote ischemic preconditioning, n = 41) and control group (without limb remote ischemic preconditioning, n = 40). The intra- and post-operative clinical data were gathered. The blood samples from radial artery were collected for oxygenation index (PaO2/FiO2) , tumor necrosis factor-α(TNF-α), interleukin-6 (IL-6) and malondialdehyde (MDA) analysis at the beginning, 6 h and 24 h after the end of surgery. Results The postoperative mechanical ventilation time of experimental group was shorter than that of control group. According to within-group comparisons , the plasm TNF-α , IL-6 and MDA levels at 6 h and 24 h after the end of surgery were higher than that at the beginning of the surgery. However, the plasm TNF-α, IL-6 and MDA levels at 6 h and 24 h after surgery in experimental group were lower than those in the control group , and the oxygenation indexs at 6 h and 24 h after surgery in experimental group were higher than those in the control group (P < 0.05). Conclusion The limb remote ischemic preconditioning, as a simple and effective pulmonary protection method , showed obvious pulmonary protective effect in thoracoscopic cardiac surgery with CPB.关键词
缺血预处理/肺保护/心脏手术/微创手术Key words
Ischemic preconditioning/ Pulmonary protection/ Cardiac surgery/ Minimally invasive surgery引用本文复制引用
雷迁,曾庆诗,罗沙,张晓慎,谢斌,朱平,罗智超,郭惠明..肢体远隔缺血预处理对胸腔镜体外循环心脏手术的肺保护作用[J].实用医学杂志,2013,29(11):1754-1756,3.基金项目
卫生部卫生行业科研专项(编号:200902001) （编号:200902001）
广东省医学科学技术研究基金项目(编号:A2012058) （编号:A2012058）
