实用医学杂志2013，Vol.29Issue(11)：1844-1846,3.DOI:10.3969/j.issn.1006-5725.2013.11.049
血清半胱氨酸蛋白酶抑制剂C 评价糖尿病患者肾小球滤过功能的临床价值
Clinical value of serum Cystatin C in the evaluation of glomerular filtration function in patients with Diabetes mellitus
摘要
Abstract
Objective To investigate the clinical value of serum Cystatin C (SCys C) in the evaluation of glomerular filtration function in patients with Diabetes Mellitus (DM). Methods The clearance of Technetium [<99m>Tc] pentetate injection (99mTc-DTPA), which was defined as the gold standard for the judgment of glomerular filtration rate(GFR) , SCys C, creatinine clearance (CCr) were measured in 55 cases of DM, and the ROC curves were used to evaluate the performance of SCys C and CCr in the diagnosis of glomerular filtration dysfunction. Results (1)The SCys C in the GFR-decline group was significantly higher than that in the GFR-normal group, while the CCr was significantly lower(P < 0.05). (2)The correlation coefficients between SCys C, CCr and 99mTc-DTPA clearance were -0.913 and 0.729 respectively (P < 0.05). (3 )The AUC of SCys C in the diagnosis of glomerular filtration dysfunction was significantly larger than that of CCr (P < 0.05) , and the best cutoff value of SCys C was 1.29 mg/L, which had a sensitivity of 84.2% , specificity of 94.4%. Conclusion The SCys C is an ideal indicator for reflecting the GFR, and it has better value in the diagnosis of kidney damage in patients with DM.关键词
糖尿病/半胱氨酸蛋白酶抑制剂C/肾小球滤过功能Key words
Cystatin C / Diabetes mellitus / Glomerular filtration function引用本文复制引用
吴世木,钱耀先,秦苑,吴海婴,张迪,华东,杨叶虹..血清半胱氨酸蛋白酶抑制剂C 评价糖尿病患者肾小球滤过功能的临床价值[J].实用医学杂志,2013,29(11):1844-1846,3.基金项目
国家自然科学基金项目(编号:81000329) （编号:81000329）
