实用医学杂志2013，Vol.29Issue(12)：1918-1920,3.DOI:10.3969/j.issn.1006-5725.2013.12.011
最佳呼气末正压对急性呼吸窘迫综合征猪模型肺内分流的影响
Effects of optimal PEEP on pulmonary shunt fraction in pig with acute respiratory distress syndrome
摘要
Abstract
Objective To investigate the changes of pulmonary shunt fraction in pig with acute respiratory distress syndrome (ARDS). Methods Eleven anaesthetized and ventilated ARDS pig models were induced by intravenously infusing oleic acid. Optimal PEEP level was determined by Optimal arterial oxygen partial pressure (PaO2) + arterial carbondioxide partial pressure (PaCO2). Intrapulmonary shunt fraction (Qs/Qt), plateau airway pressure (Pplat), static compliance (Cst), dynamic compliance (Cdyn), PaO2, mixed venous oxygen partial pressure (PvO2), arterial oxygen saturation (SaO2) and mixed venous oxygen saturation (SvO2), were recorded before infusing oleic acid, after stabilization of ARDS model and at optimal PEEP level. Statistical methods was used to investigate the effects of PaO2, PvO2, SaO2 and SvO2 on Qs/Qt. Results The optimal PEEP can decrease the intrapulmonary shunt (P < 0.05). The effective factors to Qs/Qt were SaO2, PaO2 and SvO2. Qs/Qt was significantly affected by SaO2. There was linear correlation between Qs/Qt and SaO2 and the coefficient of determination (R square) was 0.953 (P < 0.05). PvO2 and SvO2 showed no significant effect on Qs/Qt (P > 0.05). Conclusion The optimal PEEP can improve the intrapulmonary shunt. The main effective factor on Qs/Qt was SaO2.关键词
急性呼吸窘迫综合征/最佳呼气末正压/肺内分流Key words
Acute respiratory distress syndrome / Positive end expiratory pressure / Pulmonary shunt fraction引用本文复制引用
边伟帅,晁彦公,陈炜,王兰,李黎明,关键,盛博,刘平,赵磊..最佳呼气末正压对急性呼吸窘迫综合征猪模型肺内分流的影响[J].实用医学杂志,2013,29(12):1918-1920,3.基金项目
北京市卫生局重大科研项目(编号:2005-32) （编号:2005-32）
