摘要
Abstract
Objective To prospectively monitor changes iodine-water concertration with enhanced spectral CT imaging in lung cancer and to evaluate whether iodine-water concertrations correlate with response to chemotherapy. Methods Sixteen patients with lung cancer, confirmed hy histopathology and underwent chemotherapy, were enrolled in this study. Enhanced spectral CT imaging with a standard injection protocol was repeated with fast kVp switching technique at 80 and 140 kVp in pre-chemotherapy and post-chemotherapy. We measured iodine-water concertrations (IC) of each lesion in pre-chemotherapy and post-chemotherapy in plain and venous phase respectively. Using the RECIST criteria of complete response (CR) , partial response (PR) , stable disease (SD) , and progressive disease (PD) , we evaluated the patients' tumor responses after 3 months by CT scans. Results After chemotherapy, five cases had PR, nine cases had SD and two cases had PD. The difference of CT values in pre-chemotherapy and post-chemotherapy for PR , SD and PD group were 14.41 ± 10.67 , 1.49 ± 11.95 and -16.08 ± 12.58 , while the difference of iodine content (IC) values were 0.098 ± 0.69,0.28 ± 0.35 and -0.146 ± 0.86 respectively. The difference of CT values in pre-chemotherapy and post-chemotherapy for PR , SD and PD group were 17.41 ± 9.83, 5.48 ± 7.55 and -10.66 ± 8.42 in venous phase, while the difference of iodine content (IC) values were 1.24 ± 0.56, 0.87 ± 0.16 and -1.45 ± 0.44 respectively. Significant correlation was seen between changes in CT vlaue , iodine content (IC) value and tumor response to therapy in plain and venous phase (r= -0.23, P= 0.036; r = -0.60, P= 0.014; r = -0.69, P = 0. 025; r = -0.71, P = 0. 007; respectively). Conclusions Iodine-water concertrations with spectral CT imaging could be useful to assessing the response of lung cancer to chemotherapy. A combination of the RECIST criteria and iodine content change in gemstone spectral imaging are proposed for response evaluation in lung cancer.关键词
肺肿瘤/能谱CT/疗效评估Key words
Pulmonary neoplasms / Spectral CT/ Therapeutic effect
