武警医学2013，Vol.24Issue(6)：488-490,3.
丙型肝炎病毒核酸定量和抗-HCV血清学分析的诊断价值
Retrospective analysis of Antibody of HCV and quantification of HCV RNA in diagnosis of hepatitis C
刘贤华 1白晓东 2刘元明 3段萃娟 3荣冉 3刘维维2
作者信息
- 1. 100039,北京,武警总医院医疗科
- 2. 100039,北京,武警总医院烧伤整形科
- 3. 100039,北京,武警总医院检验科
- 折叠
摘要
Abstract
Objective To study the application value of hepatitis C virus RNA detection ( PCR -fluorescent probe) and hepatitis C virus antibody detection (ELISA, anti - HCV) in the diagnosis of hepatitis C. Methods The HCV - RNA and anti - HCV tests of 265 suspected HCV patients were reviewed, statistics of anti - HCV and HCV - RNA detection results and ALT level in different ages and gender was collected and analysized. Results ①Anti - HCV and HCV - RNA positive rates in men were higher than those in women, but there was no statistically significant difference (P >0. 05). ② Anti - HCV and HCV - RNA positive rates in >40 years old patients were obviously higher than those in ≤40 years old patients ,with statistically significant difference (P <0. 05) ; ALT abnormal rates also had significant difference between >40 and ≤40 years old patients (P < 0. 05). ③ ALT abnormal rate increased with increasing HCV - RNA positive rate and have positive correlation with HCV - RNA content ( r = 0. 999, P < 0. 05 ) . But the ALT levels did not correlate with HCV - RNA content ( r = 0. 800, P > 0. 05 ) . ④The abnormal rate of Anti - HCV was closely correlated with HCV - RNA ( r = 0. 320) ; Anti - HCV, HCV - RNA and ALT had no statistically significant difference ( P > 0. 05 ) . Conclusions ①Anti - HCV and HCV - RNA detection have no relation with gender, but they have certain relevance with age. ②ELISA for detecting anti - HCV is still first choice in HCV. Combined use of HCV - RNA,anti - HCV and ALT detection, will be the most reliable and valuable method in diagnosis of HCV.关键词
丙型肝炎病毒核酸定量检测/抗-HCV/诊断Key words
HCV RNA quantification/ HCV antibody/diagnosis分类
医药卫生引用本文复制引用
刘贤华,白晓东,刘元明,段萃娟,荣冉,刘维维..丙型肝炎病毒核酸定量和抗-HCV血清学分析的诊断价值[J].武警医学,2013,24(6):488-490,3.
