西安交通大学学报（医学版）2013，Vol.34Issue(4)：500-502,553,4.
EGFR/STAT信号通路相关蛋白在特发性肺纤维化中的表达及临床意义
Expression and clinical significance of the EGFR/STAT signal pathway in idiopathic pulmonary fibrosis
李龙 1杨兰生 2李慧 3胡静怡 3唐发兵 2余勤1
作者信息
- 1. 兰州大学第一医院呼吸科,甘肃兰州,730000
- 2. 兰州大学第一医院病理科,甘肃兰州,730000
- 3. 兰州大学医学院,甘肃兰州,730000
- 折叠
摘要
Abstract
Objective To investigate the expressions of epithelial growth factor receptor (EGFR), extracellular signal-regulated kinase (ERK1/2) and signal transducer and activator of transcription (STAT1) in patients with idiopathic pulmonary fibrosis (IPF) in order to explore their relationship with the clinical characteristics and prognosis of IPF. Methods The expressions of the proteins EGFR, STAT1 and ERK1/2 were assayed by an immunohistochemical method in 15 IPF specimens and 10 normal lung tissues. Results The expression rates of EGFR and STAT1 in the IPF group were 73. 3% and 66.7%, respectively. The stained points of EGFR and STAT1 were positively correlated with the total lung capacity, diffusion capacity and PaO2 level (all P< 0.05), but not correlated with the pathological characteristics or imaging features of high-resolution chest CT. EGFR and STAT1 were not significantly expressed in the normal lung tissues. ERK1/2 expression in the IPF group was not significantly increased compared with that in the normal lung tissues group (P>0.05). Conclusion The activation of the EGFR/STAT signal transduction pathway is closely related to the occurrence, progression and metastasis of IPF. Proteins such as EGFR and STAT1 can be used as valuable indicators for assessing the progression of IPF.关键词
特发性肺纤维化/表皮生长因子受体(EGFR)/ERK1/2/STAT1/肺功能Key words
idiopathic pulmonary fibrosis (IPF)/ epithelial growth factor receptor (EGFR)/ extracellular signal-regulated kinase (ERK1/2)/ signal transducer and activator of transcription (STAT1)/ lung function分类
医药卫生引用本文复制引用
李龙,杨兰生,李慧,胡静怡,唐发兵,余勤..EGFR/STAT信号通路相关蛋白在特发性肺纤维化中的表达及临床意义[J].西安交通大学学报（医学版）,2013,34(4):500-502,553,4.
