西安交通大学学报（医学版）2013，Vol.34Issue(4)：512-515,4.
2型糖尿病合并非酒精性脂肪肝患者丙氨酸氨基转移酶水平与颈动脉粥样硬化的相关性
Correlation of alanine aminotransferase and carotid atherosclerosis in type 2 diabetic patients with non-alcoholic fatty liver disease
董春萍 1吴贵福 1李晓燕 1何岚 1高珊 1李小凤1
作者信息
- 1. 陕西省人民医院内分泌科,陕西西安,710068
- 折叠
摘要
Abstract
Objective To investigate the association of alanine aminotransferase (ALT) level with glucose and lipid metabolism, insulin resistance and carotid atherosclerosis in type 2 diabetic patients with non-alcoholic fatty liver disease (NAFLD). Methods A total of 394 patients with type 2 diabetes were recruited. Based on the results of abdominal ultrasonography and plasma ALT level, they were divided into group 1 (Gl, 154 subjects without NAFLD), group 2 (G2, 170 subjects with NAFLD whose ALT<40 U/L), and group 3 (G3, 70 subjects with NAFLD whose ALT>40 U/L). Height, weight, blood pressure, liver enzymes, blood glucose and blood lipids were detected; homeostasis assessment for insulin resistance (HOMA-IR) was calculated based on oral 75 g glucose tolerance and insulin release test; the plaques in carotid arteries were measured by ultrasonography. Results The three groups differed significantly in age, diabetes duration, body mass index (BMI), triglycerides, high-density lipoprotein-cholesterol, fasting serum insulin, postprandial insulin and HOMA-IR (P<0.05); but not in carotid atherosclerosis (P>0.05). Carotid atherosclerosis was more common in patients over 65 years; NAFLD with carotid atherosclerosis was more common in patients aged 45 - 65 years. Logistic regression analysis showed that BMI and ALT were independently associated with NAFLD; age was independently associated with carotid atherosclerosis. Conclusion The increased level of ALT is closely related to BMI, lipid metabolism disorder and insulin resistance, which results in earlier onset of type 2 diabetes and carotid atherosclerosis.关键词
糖尿病/非酒精性脂肪肝/丙氨酸氨基转移酶/颈动脉粥样硬化/胰岛素抵抗Key words
type 2 diabetes/ nonalcoholic fatty liver disease/ alanine aminotransferase/ carotid atherosclerosis/ insulin resistance分类
医药卫生引用本文复制引用
董春萍,吴贵福,李晓燕,何岚,高珊,李小凤..2型糖尿病合并非酒精性脂肪肝患者丙氨酸氨基转移酶水平与颈动脉粥样硬化的相关性[J].西安交通大学学报（医学版）,2013,34(4):512-515,4.
