西安交通大学学报（医学版）2013，Vol.34Issue(4)：533-536,4.
通脑溶栓胶囊对缺血性脑损伤的保护作用
The protective effect of Tongnao thrombolysis capsule on ischemic brain damage
摘要
Abstract
Objective To study the protective effect of Tong-nao thrombolysis capsule on ischemic brain injury. Methods SD rats were randomly divided into six groups according to weight: sham group, model group, positive control group, and Tong-nao thrombolysis capsule low, medium and high dose groups. The first two groups were intragastrically administered 5 g/L CMC-Na while the other groups were intragastrically administered the corresponding volume of suspension for 30 d. The cerebral ischemia models were made after the final drug administration to observe the influences of the drug on nerve symptom, water content in brain tissues and the rate of cerebral infarction in cerebral ischemia mice. The mice were divided into 5 groups: solvent control group, positive control group, and Tong-nao thrombolysis capsule low, medium and high dose groups (10 in each group, males and females in half). The solvent control group was intragastrically administered 5 g/L CMC-Na; the other groups were intragastrically administered the corresponding volume suspension continuously for 30 d. The mice were beheaded 30 min after the final drug administration to record gasping time. Results Compared to the model group, Tong-nao thrombolysis capsule medium and high dose groups differed significantly in neurologic symptoms scores, cerebral edema and brain infarction range (P<0. 05). Low dose group had a certain pharmacology trend in improving cerebral ischemia index, but without statistical difference (P>0.05). Compared with the solvent control group, Tong-nao thrombolysis capsule low, medium and high dose groups had significantly prolonged gasping time after beheaded (P<0.05 or P<0.01). Conclusion Tong-nao thrombolysis capsule can protect the brain from hypoxia-induced damage and improve anoxia tolerance capability of brain tissues.关键词
通脑溶栓胶囊/缺血性脑损伤/神经症状评分/脑梗死Key words
Tongnao thrombolysis capsule/ ischemic brain damage/ neurologic symptoms score/ cerebral infarction分类
医药卫生引用本文复制引用
王红英,黄琳红,马耀茹,贺建宇..通脑溶栓胶囊对缺血性脑损伤的保护作用[J].西安交通大学学报（医学版）,2013,34(4):533-536,4.基金项目
科技部科技型中小企业技术创新基金(No.12C26216106788) （No.12C26216106788）
陕西省自然科学基金(No.2011JM4018) （No.2011JM4018）
