医疗卫生装备2013，Vol.34Issue(6)：17-19,3.DOI:10.7687/J.ISSN1003-8868.2013.06.017
Ⅱ型轴流泵左心辅助装置的动物体内植入实验
Animal Experiments of Type Ⅱ Axial Flow Pump for Left Ventricular Assistance
摘要
Abstract
Objective To evaluate in vivo performance and physiological effects of recently meliorated type Ⅱ axial flow pump by animal experiments.Methods Six swine,with the weights of 60-70 kg,were anesthetized intravenously and maintained with a volume-limited ventilator via a tracheotomy tube.The left chest was entered through a posterolateral thoracotomy at the fifth costal space.Then,type Ⅱ axial flow pump was placed into the thorax,bypassing the left ventricle,through an apex cut by a cannula for inflow,to the descending thoracic aorta by a side-to-end anastomosis with a artificial vessel for outflow.Two thincatheters were respectively inserted into the aortic arch via the right femoral artery for aortic pressure record and into the leftventricular via the left atrium for left ventricular pressure inspection.Results Type Ⅱ axial flow pump could be totally implanted into the thorax without difficulty.Normally,the left ventricular systolic pressure measured (137 ± 23)mmHg.Significant change in the left ventricular pressure could be induced by the start of pump.The left ventricular systolic pressure was instantly decreased with the increase of pump rotational speed,while the aortic pressure remained normal.Typically,the left ventricular systolic pressure was lowered to (32 ± 14) mmHg at the pump speed of 10 000 r/min while the aortic pressure maintained at (122 ± 28) mmHg.The results indicated that type Ⅱ axial pump could effectively unload the ventricle and sustain the normalcirculation at the same time.Conclusion Type Ⅱ axial flow pump has a good anatomic fit,and the hemodynamic feature is eligible for using as a LVAD and promises to be used in the clinical practice in near future.关键词
心脏辅助/轴流泵/人工心脏/心功能衰竭Key words
heart assist device/axial flow pump/artificial heart/cardiac failure分类
医药卫生引用本文复制引用
田步升,陈海丰,李国荣,朱晓东..Ⅱ型轴流泵左心辅助装置的动物体内植入实验[J].医疗卫生装备,2013,34(6):17-19,3.基金项目
山西省科技攻关项目 （）
