针刺研究2013，Vol.38Issue(3)：181-185,5.
经皮穴位电刺激“足三里”对运动性疲劳胃黏膜损伤大鼠胃黏膜6-酮-前列腺素1α、血栓素B2的影响
Effects of Transcutaneous Electrical Acupoint Stimulation of "Zusanli" (ST 36) on Gastric Mucosal Injury in Exercise Stress-induced Gastric Ulcer Rats
石君杰 1黄玲芬2
作者信息
- 1. 浙江医学高等专科学校,杭州310053
- 2. 浙江慈爱康复医院,杭州310012
- 折叠
摘要
Abstract
Objective To observe the effect of transcutaneous electrical acupoint stimulation (TEAS) of "Zusanli"(ST 36) on gastric mucosal injury in rats with exercise stress-induced gastric ulcer.Methods Twenty-four SD rats were randomly and equally divided into normal control,model and TEAS groups.Gastric ulcer model was established by forcing the rat to run on a treadmill (15 m/min) till exhaustion,once daily continuously for 15 days.TEAS was applied to bilateral "Zusanli" (ST 36) for 30 min,once daily for 15 days.Behavior changes (crossing and rearing scores) were assessed using open-field test.The ulcer index (UI) of the gastric mucosa was measured by giving the mottling bleeding,streak-like hemorrhage and lesion width with scores according to Guth's method.Contents of 6-keto-prostaglandin F1α (6-keto-PGF1α) and thromboxane B 2 (TXB2) of gastric mucosal tissue were measured using radioimmunoassay.Results Compared with the normal group,the levels of crossing and rearing levels in open-field tests,and the duration of forced treadmill running exhaustion,gastromocosal 6-keto-PGF1α and TXB2 contents in the model group were obviously reduced(P＜0.01),while the UI of model group was obviously increased (P＜0.01).In comparison with the model group,the scores of crossing and rearing in open-field tests and the duration of forced treadmill running exhaustion and gastromocosal 6-keto-PGF1α and TXB2 contents of TEAS group were significantly increased (P＜0.05),and the UI of TEAS group was obviously decreased(P＜0.05).Conclusion TEAS of "Zusanli"(ST 36) can protect gastric mucosa from injury in exercise stress-induced gastric ulcer rats.关键词
经皮穴位电刺激/足三里/运动性疲劳/胃黏膜损伤Key words
Transcutaneous electrical acupoint stimulation (TEAS)/Zusanli (ST 36)/Exercise-induced fatigue/Gastromucosal injury分类
医药卫生引用本文复制引用
石君杰,黄玲芬..经皮穴位电刺激“足三里”对运动性疲劳胃黏膜损伤大鼠胃黏膜6-酮-前列腺素1α、血栓素B2的影响[J].针刺研究,2013,38(3):181-185,5.
