中国病理生理杂志2013，Vol.29Issue(6)：1133-1135,1141,4.DOI:10.3969/j.issn.1000-4718.2013.06.030
人食管鳞癌组织中RhoC和Ki-67的表达及意义
Expression and clinical significance of RhoC and Ki-67 in human esophageal squamous cell carcinoma tissues
摘要
Abstract
AIM:To investigate the expression and significance of RhoC and Ki-67 in human esophageal squamous cell carcinoma (ESCC) tissues.METHODS:The expression of RhoC and Ki-67 was detected in 52 specimens of ESCC by the method of immunohistochemistry.The clinicopathological features were also analyzed.RESULTS:The expression of RhoC was detected in 32 of the total 52 (61.5％) cases of human ESCC tissues,significantly higher than that in the adjacent histologically normal epithelium,which was only in 11 of 37 cases (29.7％,P ＜ 0.05).RhoC expression was closely correlated with clinical tumor-node-metastasis (TNM) stage (P ＜ 0.05) and lymph node metastasis (P ＜0.05) in ESCC.The over-expression of RhoC was positively correlated with Ki-67 in ESCC (r =0.322,P ＜ 0.05).CONCLUSION:The over-expression of RhoC protein significantly correlates with advanced TNM stage,lymph node metastasis and cell proliferation ability of ESCC.Therefore,RhoC may be a new auxiliary parameter for early diagnosis and prognostic evaluation of ESCC.关键词
食管肿瘤/RhoC蛋白/Ki-67抗原Key words
Esophageal neoplasms/RhoC protein/Ki-67 antigen分类
医药卫生引用本文复制引用
林尤恩,倪仰鹏,王晓芬,王春冰..人食管鳞癌组织中RhoC和Ki-67的表达及意义[J].中国病理生理杂志,2013,29(6):1133-1135,1141,4.
