中国当代儿科杂志2013，Vol.15Issue(6)：484-489,6.DOI:10.7499/j.issn.1008-8830.2013.06.020
最大长度序列脑干听觉诱发电位在头部低温治疗新生猪缺氧缺血性脑损伤中的动态变化
Changes in MLS-BAEP in newborn piglets with hypoxic-ischemic brain damage during selective moderate head cooling therapy
汪吉梅 1周文浩 2程国强 2王来栓 2蒋泽栋 2邵肖梅2
作者信息
- 1. 复旦大学附属妇产科医院新生儿科,上海200011
- 2. 复旦大学附属儿科医院新生儿科,上海201102
- 折叠
摘要
Abstract
Objective To study the effect of selective moderate head cooling therapy on maximum length sequences brainstem auditory evoked potential (MLS-BAEP) in newborn piglets with hypoxic-ischemic brain damage.Methods Sixteen newborn piglets aged 5-7 day old were randomly divided into three groups:normothermic control (n =4),HI (n =6) and mild hypothermia-treated (n =6).HI was induced through temporary occlusion of both carotid arteries,followed by mechanical ventilation with low concentration of oxygen (FiO2 =0.06) for 30 minutes.Mild hypothermia was induced by equipment via circulating water.MLS-BAER was recorded before HI and at 12 hours,24 hours,36 hours,48 hours,60 hours,72 hours,4 days,7 days,10 days,13 days and 15 days after HI.Results Compared with the normothermic control group,all latencies and intervals tended to increase significantly at 72 hours in the HI group and reached peak values on day 7.From day 10,all latencies and intervals tended to decrease,but apart from wave I latency,still differed significantly from those of the normothermic control group.MLS-BAER variables did not reach normal values until day 15.Ⅲ latency,Ⅰ-Ⅲ interval and Ⅰ-Ⅴ interval were significantly reduced in the hypothermia-treated group between 60 and 7 days after HI compared with the HI group (P ＜ 0.05).Ⅴ latency and Ⅲ-Ⅴ interval in the hypothermia-treated group were also reduced compared with the HI group between 72 hours and 7 days after HI (P ＜ 0.05).Conclusions Both peripheral and central auditory systems are disturbed by HI,which shows as a significant increase in MLS-BAER variables (all latencies and intervals) in newborn piglets.Involement in central brainstem auditory system reaches a peak on day 7 after injury.MLS-BAER variables still cannot reach to normal values until day 15.Selective moderate head cooling therapy can significantly reduce brainstem damage induced by HI.关键词
低温/缺氧缺血脑损伤/最大长度序列脑干听觉诱发电位/新生猪Key words
Mild hypothermia/ Hypoxic-ischemic brain damage/ Maximum length sequence brainstem auditory evoked potential/ Newborn piglets引用本文复制引用
汪吉梅,周文浩,程国强,王来栓,蒋泽栋,邵肖梅..最大长度序列脑干听觉诱发电位在头部低温治疗新生猪缺氧缺血性脑损伤中的动态变化[J].中国当代儿科杂志,2013,15(6):484-489,6.
