中国临床药理学与治疗学2013，Vol.18Issue(6)：610-613,4.
人组织激肽释放酶对大鼠坐骨神经损伤的修复作用
Repair effect of human tissue kallikrein on sciatic nerve injury of rats
摘要
Abstract
AIM:To study the repair effect of human tissue kallikrein (HTK) on sciatic nervous of rats.METHODS:Thirty-six adult male SD rats weighted 180-220 g were randomly divided into 3 groups.The control group was just injected with 2 mL salt water by caudal vain every day.The SM group was injected with methylprednisolone 30 mg/kg(2 mL)by caudal vain every day.The HTK group was injected with human tissue kallikrein 17.5 × 10-3 PNAU/kg (2 mL) by caudal vain every day.The sciatic functional index (SFI) at the day 1,3,5,7,9,11 and 13 after operation in all rats were calculated.The nerve conduction velocity of the sciatic nerve at the 14th day postoperation was observed.RESULTS:All rats showed-100 at day 1 and 3.The HTK group and the SM group showed a statistically significant improvement over the control group from the 3th day postoperation.The NCV of the HTK group and the SM group were greater than the control group (P＜0.05).CONCLUSION:The repair effect of human tissue kallikrein (HTK) on sciatic nervous of rats was effective.关键词
人组织激肽释放酶/坐骨神经损伤/激素/修复作用Key words
Human tissue kallikrein/ Sciatic nervous injury/ Hormone/ Repairation分类
医药卫生引用本文复制引用
耿武军,刘珺,唐红丽,莫云长,王丹丹,王均炉..人组织激肽释放酶对大鼠坐骨神经损伤的修复作用[J].中国临床药理学与治疗学,2013,18(6):610-613,4.基金项目
温州市科技局项目(Y20100217) （Y20100217）
