中国临床药理学杂志2013，Vol.29Issue(6)：413-415,3.
银杏叶与盐酸多奈哌齐治疗老年轻度认知功能障碍的临床效果
Comparative analysis of clinical effect of ginkgo biloba and hydrochloride donepezil on elderly patients with mild cognitive impairment
项迎春 1戴丽2
作者信息
- 1. 浙江医院药剂科,杭州 310012
- 2. 浙江上虞中医院临床药学室,浙江上虞 312300
- 折叠
摘要
Abstract
Objective To evaluate the clinical efficacyof ginkgo biloba and donepezil hydrochloride on the elderly with mild cognitive impairment (MCI).Methods A total of 125 patients with MCI were divided into ginkgo biloba treatment group (treatment group,65 cases) and donepezil hydrochloride group (control group,60 cases).The mini-mental status evaluation form (MMSE) was used for the evaluation of clinical symptoms in the two groups,and P300 and EEG changes were observed.Results The total response rate of treatment group were 89.23％,while the control group were 76.67％.Compared with before treatment,the MMSE of two groups was significantly improved after treatment,and the treatment group were significant increased compared with the control group (P ＜ 0.05).EEG abnormality rate of treatment group was 27.69％,while the control group was 46.67％ after treatment.The difference of abnormal EEG between two groups was statistically significant(P ＜0.05).The P300 amplitude of patients in two groups has rise and the incubation period has shortened after treatment.Changes in the treatment group were significantly greater than the control group (P ＜0.05).Conclusion The effectiveness of Ginkgo biloba is better than donepezil hydrochloride.It can improve MCI patients activity in the brain as well as cognitive ability.关键词
银杏叶/盐酸多奈哌齐/老年人/轻度认知功能障碍Key words
ginkgo biloba preparations/ donepezil hydrochloride/ elderly/ mild cognitive impairment分类
医药卫生引用本文复制引用
项迎春,戴丽..银杏叶与盐酸多奈哌齐治疗老年轻度认知功能障碍的临床效果[J].中国临床药理学杂志,2013,29(6):413-415,3.
