中国临床药理学杂志2013，Vol.29Issue(6)：419-422,4.
阿立哌唑联合利培酮治疗慢性精神分裂症对照研究
A controlled study on aripiprazole combined with risperidone in the treatment of chronic schizophrenia
摘要
Abstract
Objective To evaluate the effectiveness and safety of aripiprazole combined risperidone in the treatment of chronic schizophrenia.Methods A total of 212 patients diagnosed as chronic schizophrenia were randomly divided into aripiprazole combined risperidone group (treatment group,n =105) and risperidone group (control group,n =107).Clinical effectiveness was assessed with the positive and negative syndrome scale(PANSS)and adverse reactions with the treatment emergent symptom scale (TESS) before treatment and at the end of the 2,4,8 week.Results One hundred and five patients of the treatment group and 104 patients of the control group had completed the course.The effective rate and the apparent effect rate in treatment group was 92.38％ and 77.14％,whereas that was 85.58％ and 66.35％ in control group.There was no significant difference between two groups (P ＞ 0.05).Effectiveness of treatment group was superior to control group at the end of the 2,4,8 week by PANSS total scores'subtraction and PANSS negative scores" subtraction (P ＜ 0.01).Compared with control group,treatment group had significantly fewer adverse drug reaction in the symptoms of tremor,akathisia,weight gain,lactation and menstrual disorder (P ＜ 0.05).Conclusion Aripidrazole combined risperidone are effective and safe in the treatment of chronic schizophremia.关键词
阿立哌唑/利培酮/慢性精神分裂症Key words
aripiprazole / risperidonel / chronic schizophrenia分类
医药卫生引用本文复制引用
杨永秀,陈斌华,徐小杰,陶云海,施剑飞..阿立哌唑联合利培酮治疗慢性精神分裂症对照研究[J].中国临床药理学杂志,2013,29(6):419-422,4.基金项目
浙江省医药卫生科学研究基金资助项目(2010KYA165),杭州市卫生局医疗卫生科研基金资助项目(20100633B20) （2010KYA165）
