中国临床药理学杂志2013，Vol.29Issue(6)：443-445,3.
瑞舒伐他汀预处理对大鼠脑缺血再灌注损伤的神经保护作用
Neuroprotective effects of rosuvastatin preconditioning on cerebral ischemia reperfusion injury in rats
李国前 1杨小霞 1王杰华 1陈春雷2
作者信息
- 1. 福建医科大学附属泉州第一医院神经内科,福建泉州 362000
- 2. 南安市第二医院神经内科,福建泉州 362000
- 折叠
摘要
Abstract
Objective To investigate the effects of rosuvastatin preconditioning on apoptosis and the apoptosis-related proteins in rats with focal cerebral ischemia-repedusion.Methods Forty eight male adult Sprague-Dawley rats were randomly assigned into four groups:Sham operation group(sham group),focal cerebral ischemia-reperfusion group (I/R group),vehicle adminerstration group(vehicle group),and rosuvastatin preconditioning group (test group).Before making a model,the rats in the test group were lavaged with rosuvastatin 5 mg · kg-1 · d-1,once a day for 10 consecutive days,and the same volume of normal saline was lavaged in the vehicle group.The middle cerebral artery occlusion reperfusion model was made by the suture method (ischemia for 2 hours,and reperfusion for 24 hours).After that,the animals were neurologically assessed on a 5 point scale.Rats were sacrificed by decapitation.TUNEL staining was used to observe neuron apopotosis.The level of caspase-3 and caspase-9 expression were measured by immunohistochemical.Results Compared with I/R group and vehicle group,neurological functions were better in test group,TUNEL positive cells and caspase-3,caspase-9 immunoreative neurons in the rats of test group were downregnlated (P ＜ 0.05).Conclusion Rosuvastatin can suppress neurocyte apoptosis in cerebral ischemia,whose mechanisms seemed related to inhibiting the expression of caspase-3 and caspase-9.关键词
瑞舒伐他汀/脑缺血再灌注/细胞凋亡Key words
rosuvastatin/ cerebral ischemia-reperfusion/ apoptosis分类
医药卫生引用本文复制引用
李国前,杨小霞,王杰华,陈春雷..瑞舒伐他汀预处理对大鼠脑缺血再灌注损伤的神经保护作用[J].中国临床药理学杂志,2013,29(6):443-445,3.
