中国全科医学2013，Vol.16Issue(12)：1349-1352,4.DOI:10.3969/j.issn.1007-9572.2013.04.085
肝癌术中丝裂霉素纤维蛋白胶局部缓释化疗的应用效果研究
Local Sustained-release Chemotherapy by Fibrin Glue Enwrapping Mitomycin in Hepatectomy Operation
摘要
Abstract
Objective To explore the effect of local sustained - release chemotherapy by fibrin glue enwrapping mitomycin in hepatectomy operation. Methods Thirty liver cancer patients admitted from July 2007 to Jane 2009 were divided randomly into groups observation and control, 15 in each. Control group were given only surgical treatment, observation group given local sustained - release chemotherapy by fibrin glue enwrapping mitomycin ( 2. 5 ml ) after removal of tumors. Liver function indicators , serum alpha - fetoprotein ( AFP ) level, prothrombin time ( PT ) were observed before operation and 1 , 3 , 6, 12 months after operation; Median tumor - free survival time recorded; 1 - , 2 - , 3 - year tumor - free survival rates calculated. Recurrence influencing factors were analyzed by Cox hazard regression model. Results There was no significant difference in liver function indicators, serum AFP level, PT between the two groups before operation ( P > 0. 05 ), but there was in serum AFP level 1, 3 , 6 , 12 months after operation ( P <0. 05 ), not in liver function indicators or PT ( P > 0. 05 ). The median tumor -free survival time was 15. 5 months in control group [ 95% CI ( 13. 9, 17. 6 ) ], 21. 3 months in observation group [ 95% CI ( 2. 4, 28. 2 ) ], the difference was significant ( x2 = 6. 190, P < 0. 05 ); the 1 - , 2 - , 3 - year tumor - free survival rates were 62. 2% , 40. 4% , 12. 7% , respectively in control group, 81. 3% , 54. 6% , 30. 7% , respectively in observation group, the differences was all significant ( x2 = 4. 013 , 4. 267 , 4. 826, P <0. 05 ). By Cox hazard regression model, the influence of intraoperative sustained - release chemotherapy, number of tumor nodules on Cox hazard regression model was significant ( P < 0. 05 ). Conclusion Sustained - release chemotherapy by fibrin glue enwrapping mitomycin in hepatectomy operation, delaying early recurrence of hepatocellular carcinomas and decreasing serum AFP, has no significant effect on liver function.关键词
肝肿瘤/化学疗法,肿瘤,局部灌注/丝裂霉素/纤维蛋白组织黏着剂Key words
Liver neoplasms/ Chemotherapy, cancer, regional perfusion/ Mitomycin/ Fibrin tissue adhesive分类
医药卫生引用本文复制引用
殷香保,邬林泉,罗志强,娄思源,方路,傅华群..肝癌术中丝裂霉素纤维蛋白胶局部缓释化疗的应用效果研究[J].中国全科医学,2013,16(12):1349-1352,4.基金项目
江西省科学技术厅科技计划资助项目(2006) （2006）
江西省自然科学基金资助项目(2008GQY0050) （2008GQY0050）
