中国全科医学2013，Vol.16Issue(17)：1945-1948,4.DOI:10.3969/j.issn.1007-9572.2013.06.041
脑电图和脑干听觉诱发电位动态检测对急性一氧化碳中毒后迟发性脑病的预测价值研究
Electroencephalogram and Brainstem Auditory Evoked Potential Determining Dynamically Delayed Encephalopathy after Acute Carbon Monoxide Poisoning
摘要
Abstract
Objective To observe the dynamic changes of electroencephalogram ( EEG ) and brainstem auditory e-voked potential ( BAEP ) in patients with acute carbon monoxide poisoning ( ACMP ), to find out their predictive values for delayed encephalopathy after acute carbon monoxide poisoning ( DEACMP ). Methods A total of 83 acute carbon monoxide poisoning ( ACMP ) patients were divided, according to occurrence of DEACMP, into groups DEACMP ( n = 32 ) and non -DEACMP ( n =51 ). Patients were given EEG and BAEP on days 1~5, 8~12, 18~22, 28~32, 38~42, 52 ~57. The abnormal rates of EEG, BAEP at different time points were compared, and the sensitivity and specificity of EEG, BAEP or of their combination calculated in predicting DEACMP. Results The abnormal rates of the 1st, 4th, 5th, 6th EEG measurement were significantly higher in DEACMP group than those in non - DEACMP group ( P < 0. 05 ); The abnormal rates of the 1st, 3rd, 4th, 5th, 6th BAEP higher in DEACMP group than in non - DEACMP group ( P <0. 01 ). The first EEG was abnormal in 58 patients ( 69.9% ), including 27 patients who developed to DEACMP. The sensitivity of EEG predicting DEACMP was 84. 4% ( 27/32 ), specificity was 39. 2% ( 20/51 ). The first BAEP was abnormal in 23 patients ( 27. 7% ), including 19 patients who developed to DEACMP. The sensitivity of BAEP predicting DEACMP was 59. 4% ( 19/32 ), specificity was 92. 2% ( 47/51 ). The sensitivity of EEG combined with BAEP was 93. 7% , if 1 item being positive was taken as positive, the sensitivity was 93. 7% , specificity was 36. 1% ; If 2 items being positive was taken as positive, the sensitivity was 50. 1% , specificity was 95. 2% . Dynamical EEG or BAEP showing condition of abnormality - improvement - reabnormality predicted highly the incidence of DEACMP. Conclusion Early dynamical EEG and BAEP are of great significance and clinical values after ACMP, which is worth popularizing and applying.关键词
一氧化碳中毒/迟发性脑病/脑电图/诱发电位,听觉,脑干Key words
Carbon monoxide poisoning/ Delayed encephalopathy/ Electroencephalogram/ Evoked potentials, auditory , brain stem分类
医药卫生引用本文复制引用
王传升,石金河,靳玫,顾仁骏,张萍,韩永凯,穆俊林,顾家鹏,时婷婷,赵建民,吴强,赵建华..脑电图和脑干听觉诱发电位动态检测对急性一氧化碳中毒后迟发性脑病的预测价值研究[J].中国全科医学,2013,16(17):1945-1948,4.基金项目
河南省科技厅科技攻关计划资助项目(0624410035),河南省卫生科技创新人才资助项目(3052) （0624410035）
