中国全科医学2013，Vol.16Issue(17)：1949-1951,3.DOI:10.3969/j.issn.1007-9572.2013.06.042
急性一氧化碳中毒后迟发性脑病患者血清白介素18水平及临床意义研究
Serum IL-18 Levels and Its Clinical Significance in the Blood of Patients with Delated Encephalopathy after Acute Carbon Monoxide Poisoning
摘要
Abstract
Objective To investigate the relationship between dynamic changes of serum IL - 18 level and mechanism of delayed encephalopathy after acute carbon monoxide poisoning ( DEACMP ) to find potential cytokine variation during DEAC-MP occurrence and to provide evidence for further study on immunological mechanism of DEACMP. Methods 40 DEACMP patients admitted to the Neurology Department of our hospital from January 2009 to January 2011 were selected as DEACMP group and another 36 healthy people underwent physical examination in the same period were selected as control group. Enzyme - linked Immunoassay ( ELISA ) method was used to detect the levels of IL - 18 in acute stage and recovery stage, and the results were compared with the control group. Results The levels of IL - 18 in DEACMP patients [ ( 29. 7 ± 8. 4 ) ng/L, ( 28. 3 ± 7. 9 ) ng/L ] were significantly higher than the control group [ ( 24. 1 ±5.3) ng/L, ( 24. 1 ±5.3 ) ng/L ] both in acute stage and recovery stage ( t =3. 433 , P = 0. 001 ; t = 2. 693 , P =0. 009 ). In DEACMP group, the IL - 18 level in acute stage was significantly higher than that of recovery stage ( t = 2. 421, P=0. 020 ). Conclusion IL - 18 might be involved in the occurrence of DEACMP in a delayed immunologic way, and play a part in its development.关键词
一氧化碳中毒/缺氧缺血/脑,白细胞介素18/酶联免疫吸附测定Key words
Carbon monoxide poisoning/ Hypoxia - ischemia, brain/ Interleukin - 18/ Enzyme - linked immu- nosorbent assay分类
医药卫生引用本文复制引用
张萍,王传升,韩永凯,赵国有,顾家鹏,魏蕤荭,顾仁骏..急性一氧化碳中毒后迟发性脑病患者血清白介素18水平及临床意义研究[J].中国全科医学,2013,16(17):1949-1951,3.基金项目
河南省教育厅自然科学研究计划项目(2011B320011) （2011B320011）
