中国全科医学2013，Vol.16Issue(17)：1952-1955,4.DOI:10.3969/j.issn.1007-9572.2013.06.043
急性一氧化碳中毒后迟发性脑病患者血清胰岛素样生长因子-1水平及其临床意义研究
Serum IGF-1 Level in Patients with Delayed Encephalopathy after Acute Carbon Monoxide Poisoning and Its Clinical Significance
摘要
Abstract
Objective To investigate the dynamic changes of level of serum insulin - like growth factor - 1 ( IGF - 1 ) and its clinical significance in patients with delayed encephalopathy after acute carbon monoxide poisoning ( DEACMP ). Methods 33 DEACMP patients were selected form November 2007 to Jun 2008, IGF - 1 level was assayed with enzyme - linked im-munno - sorbent assay ( ELISA ). Their condition changes were evaluated with Activity of Daily Living Scale ( ADL ), Information - Memory - Concentration Test ( IMCT ) and Hasegawa's Dementia Scale ( HDS ). The above indexes were compared with those of 32 acute carbon monoxide poisoning ( ACMP ) patients without occurrence of DEACMP ( ACMP group ) and of 32 healthy subjects ( control group ). Results ( 1 ) IGF - 1 at acute stage was significantly lower in DEACMP group [ ( 136. 10 ±51. 51 ) μg/L ] than in control group [ ( 192. 91 ± 145. 97 ) μg/L, P < 0. 05 ], there was no significant difference in IGF - 1 at acute stage between groups DEACMP and ACMP [ ( 156. 51 ± 93. 13 ) μg/L ], between groups ACMP and control ( P >0. 05 ). IGF - 1 was higher at recovery stage [ ( 187. 69 ±92. 46 ) μg/L ] than at acute stage in DEACMP group, the difference was significant (P <0. 05 ). (2) ADL, HDS, IMCT at acute stage was significantly different from those at recovery stage in DEACMP group ( P < 0. 05 ). ( 3 ) IGF - 1 was negatively correlated with ADL in DEACMP group ( r = - 0. 377 , P = 0. 03 ). Conclusion IGF - 1, protecting probably DEACMP patients from brain damage, may be used as one of indexes for clinical outcomes and therapeutic effectiveness assessment.关键词
一氧化碳中毒/缺氧缺血,脑/胰岛素样生长因子ⅠKey words
Carbon monoxide poisoning/ Hypoxia - ischemia, brain/ Insulin like growth factor I分类
医药卫生引用本文复制引用
顾家鹏,李艳丽,王冀康,张萍,顾仁骏,李静,潘登,衣学伟,史玫,高琦..急性一氧化碳中毒后迟发性脑病患者血清胰岛素样生长因子-1水平及其临床意义研究[J].中国全科医学,2013,16(17):1952-1955,4.基金项目
新乡市科技发展计划项目(09S033) （09S033）
