Abstract
Objective To discuss the correlation between sleep structure and cognitive function in cerebral infarction ( CI) patients combined with obstructive sleep apnea hypopnea syndrome ( OSAHS ). Methods Polysomnography was performed and Mini - mental state examination ( MMSE ), Montreal Cognitive Assessment ( MoCA ) were used to evaluate cognitive function. A correlation test was performed by Spearman correlation analysis on cognitive function and parameter, staging of sleep apnea. Results In sleep structure and cognitive score, the proportion of non - rapid eye movement ( NREM ) staging and NREM 1 staging was higher in group A than in group B, that of NREM 3+4 staging, rapid eye movement ( REM ) staging lower than in group B, MMSE, MoCA scores lower than in B group, the difference was significant ( P <0. 05 ). MMSE was positively correlated with night mean SaO2, night lowest SaO2, NREM 3+4 staging ( r =0. 445 , 0. 430, 0. 491, P < 0. 05 ), negatively correlated with AHI, SaO2 reduction index ( ODI ), NREM 1 + 2 staging ( r = - 0. 428 , - 0. 640, - 0. 436 , P < 0. 05 ), and not correlated linearly with microarousal index, REM staging in group A ( P >0. 05 ). MoCA was positively correlated with night mean SaO2 , night lowest SaO2 ( r = 0. 441 , 0. 427, P < 0. 05 ), negatively correlated with AHI, ODI, NREM 1 + 2 staging ( r = - 0. 457 , - 0. 463 , - 0. 378 , P < 0. 05 ), and not correlated linearly with microarousal index, NREM 3+4 staging, REM staging in group A ( P >0. 05 ). MMSE was not correlated linearly with night mean SaO2, night lowest SaO2, AHI, ODI, microarousal index, NREM 1 +2 staging, NREM 3+4 staging or REM staging in group B ( P >0. 05 ). MoCA was negatively correlated with ODI, microarousal index ( r = - 0. 433 , - 0. 448 , P < 0. 05 ), positively with REM staging ( r = 0. 440 , P <0. 05 ), not correlated linearly with night mean SaO2, night lowest SaO2 , AHI, NREM 1+2 staging, NREM 3+4 staging in group B ( P>0. 05 ). Conclusion CI patients combined with OSAHS have obvious sleep structure disorders and severe damages of cognitive function, showing that OSAHA may aggravate neurological damages and cognitive function disorders in CI patients.关键词
睡眠呼吸暂停,阻塞性/脑梗塞/睡眠障碍/睡眠结构/认知功能Key words
Sleep apnea, obstructive/ Cerebral infarction/ Sleep disorders/ Sleep structure/ Cognitive function分类
医药卫生
