中国全科医学2013，Vol.16Issue(18)：2076-2079,4.DOI:10.3969/j.issn.1007-9572.2013.06.082
糖尿病合并格雷夫斯病的临床特点研究
The Clinical Features of Diabetes Mellitus Combined with Graves Disease
摘要
Abstract
Objective To evaluate the clinical features of diabetes mellitus combined with Graves disease. Methods A total of 44 hospitalized patients diagnosed as diabetes mellitus combined with Graves disease in Department of Endocrinology and Metabolism of Shanghai Jiaotong University Affiliated Sixth People's Hospital from 2009 to 2011 were divided into three groups by the onset time of each disease: diabetes mellitus onset first ( group A, 25 cases ), Graves disease onset first ( group B, 5 cases ) and simultaneous onset ( Group C, 14 cases ) . Retrospective analysis were performed to compare clinical characteristics, classification of diabetes mellitus, islet β cell function, blood glucose, blood lipid [ total cholesterol ( TC ), triglyceride ( TG ), low density lipoprotein ( LDL ), high density lipoprotein ( HDL ) ], symptoms and signs of Graves disease, thyroid function, thyroid auto - antibodies [ thyrotropin receptor antibody ( TR - Ab ), anti - thyroglobulin antibody ( TG - Ab ), anti - thyroid peroxidase antibody ( TPO - Ab ) ], acute complications of diabetes mellitus as well as complications of Graves disease among groups. Results Comparisons of age of onset, proportion of family history of Graves disease, the level of TG, TG - Ab and TPO - Ab titre were significantly different ( P < 0. 05 ); The age of onset and the level of TG in group C was significantly lower than those in the group A and group B, and group C had significantly higher level of family history of Graves disease, TG - Ab and TPO - Ab titre as compared with group A and group B ( P < 0. 05 ) . There was no significant difference in the incidence of ketoacidosis and complications of Graves disease among three groups ( P > 0. 05 ) . Conclusion Patients with simultaneous onset of diabetes mellitus and Graves disease present with lower onset age and lower serum TG level and higher level of family history of Graves disease as well as serum TG - Ab and TPO - Ab.关键词
糖尿病/格雷夫斯病/发病年龄/三酰甘油/格雷夫斯病家庭史/甲状腺球蛋白抗体/甲状腺过氧化物酶抗体Key words
Diabetes mellitus/ Graves disease/ Age of onset/ Triglyceride/ Family history of Graves disease/ Anti - thyroglobulin antibody/ Anti - thyroid - peroxidase antibody分类
医药卫生引用本文复制引用
裴国勇,李连喜..糖尿病合并格雷夫斯病的临床特点研究[J].中国全科医学,2013,16(18):2076-2079,4.基金项目
国家自然科学基金面上项目(81170759) （81170759）
