中国全科医学2013，Vol.16Issue(18)：2085-2088,4.DOI:10.3969/j.issn.1007-9572.2013.06.085
γ-谷氨酰转移酶与代谢综合征及各组分的相关性研究
Relationship between γ-glutamyl Transferase Enzyme and the Metabolic Syndrome
摘要
Abstract
Objective To analyze the characteristics of various liver enzymes in patients with metabolic syndrome, and to explore the relationship between γ - glutamyl transferase enzyme and the metabolic syndrome. Methods 471 cases receiving physical examination in our hospital from 2007 to 2010 were enrolled and followed up once a year for three years. Their height, weight, waist circumference ( WC ) and blood pressure ( BP ) were recorded. Alanine aminotransferase ( ALT ), aspartate amin-otransferase ( AST ), alkaline phosphatase ( ALP ), γ - glutamyl transferase ( GGT ), total cholesterol ( TC ), triglyceride ( TG ), high - density lipoprotein ( HDL ), low - density lipoprotein ( LDL ), fasting blood glucose ( FBG ), fasting insulin ( FINS ) were examined and body mass index ( BMI ), insulin resistance index ( HOMA - IR ) were also calculated. Results ( 1 ) Compared with the non - metabolic syndrome group, the proportion of male, age, WC , BP, TC, TG, FPG, HOMA -IR, ALT, AST, ALP and GGT were significantly higher and the level of HDL was significantly lower in metabolic syndrome group ( P <0. 05 ) . ( 2 ) GGT was associated with MS ( OR = 1. 041, 95% CI ( 1. 020, 1. 063 ) ] in logistic regression model in which MS in 2010 was regarded as the dependent variable and ALT, AST, ALP, GGT level in 2007 were regarded as the independent variable. ( 3 ) The level of GGT within non - metabolic syndrome group in 2007 was divided into quartiles [ Q1 group ( GGT < 14 U/L ), Q2 group ( GGT within 14 ~ 20 U/L ), Q3 group ( GGT within 21~30 U/L ), Q4 group ( GGT > 30 U/L ) ]and MS in 2010 was regarded as the dependent variable, and then the comparison of the risk factors were performed. The result suggested that the level of GGT was higher in Q3 and Q4 group than Q1 group in modell and model2, showing statistically significant differences ( P <0. 05 ), and the level of GGT was higher in Q4 group than Q1 group in model3 , also showing statistically significant difference ( P <0. 05 ), and there were no different in model4 and model5. ( 4 ) Logistic regression analysis was performed between different levels of GGT and WC, TG, HDL, BP and FPG. The results showed that compared with Q1 group, Q2, Q3 and Q4 groups showed statistically significant differences when TG and BP being the dependent variables ( P < 0. 05 ). And compared with Ql group, Q3 and Q4 groups showed statistically significant differences when WC and FPG being the dependent variables ( P <0. 05 ) . However, when HDL being the dependent variable, the difference was not statistically significant ( P > 0. 05 ). Conclusion γ - glutamyl transferase enzyme level was associated with metabolic syndrome. The risk of WC , TG, BP and FPG will rise with the increase of GGT level.关键词
代谢综合征/γ-谷氨酰转移酶/相关性Key words
Metabolic syndrome/ Gamma - glutamyltransferase/ Correlation分类
医药卫生引用本文复制引用
康慨,姜涛,宋秀霞,程飞,姚晓爱..γ-谷氨酰转移酶与代谢综合征及各组分的相关性研究[J].中国全科医学,2013,16(18):2085-2088,4.基金项目
铁道部科技研究开发计划(2011Z004-F) （2011Z004-F）
