摘要
Abstract
Objective To investigate the epidemiological characteristic and resistance of hospital - acquired infection in the elderly patients with methicillin resistant staphylococcus aureus ( MRSA ) and to evaluate the therapeutic effect and drug safety of Linezolid in MRSA infection. Methods A retrospective investigation method was used to collect data of 93 hospital - acquired infection cases from February 2010 to June 2011 in order to understand the distribution, infection risk factors of MRSA and antibiotics -use. Then retrospective analysis was conducted on the clinical data about 31 patients with hospital - acquired MRSA infection treated with linezolid and 27 patients with hospital - acquired MRSA infection treated with vancomycin. Therapeutic efficiency , bacterial clearance and adverse effects of linezolid and vancomycin for hospital - aquired MRSA infection were compared. Results The infection rate of MRSA in the Department of Respiratory Medicine was the highest than any other departments , which accounting for 23. 7% ( 22/93 ) . Lower respiratory tract was the main infection site, accounting for 62. 4% ( 58/ 93 ) . There were several factors associated with prognosis according to multivariate analysis: People who were in hospital more than 4 weeks, who were treated with broad - spectrum antibiotics more than 2 weeks, who have serious brain disease, and patients with mechanical ventilation. Linezolid group: cure rate was 87. 1% , bacterium clearance rate was 90. 3% and adverse -effect was found in 5 out of the 31 cases. Vancomycin group: cure rate was 51. 8% , bacterium clearance rate was 40. 7% , and adverse - effect was found in 4 out of the 27 cases, and the cure rate, bacterium clearance rate and adverse effect between the two groups showed statistically significant differences (x2 =9. 251, 19.521 and 4.566, P < 0. 05 ) . Conclusion The key measures to prevent hospital - acquired infection MRSA are susceptible patient taking effective disinfection, reducing invasive procedures and using antibiotics drugs rationally. Linezolid has advantages compared with Vancomycin in clinical using which including therapeutics - choice and safety - concern for gerontal - patients with MRSA infection.关键词
利奈唑胺/葡萄球菌,金黄色/耐甲氧西林/医院感染/流行病学Key words
Linezolid/ Staphylococcus aureus/ Methicillin - resistant/ Hospital infections/ Epidemiology分类
医药卫生
