中国输血杂志2013，Vol.26Issue(5)：443-445,3.
丙型肝炎病毒总抗原检测用于病程监测的研究
Clinical investigation on the hepatitis C virus total antigen detection for monitoring of hepatitis C
李洪臣 1周见远 2周咏武 2欧兰香 2胡道奇 2李莉 3张纵 3谭德明 4刘洪波4
作者信息
- 1. 秦皇岛市第一医院检验科,河北秦皇岛066000
- 2. 湖南康润药业有限公司
- 3. 济南市传染病医院
- 4. 中南大学湘雅医学院
- 折叠
摘要
Abstract
Objective To investigate the clinical significance of total antigen detection in patients with chronic hepatitis C.Methods Sera from 40 consecutive patients with chronic hepatitis C were investigated for the presence of total antigen by ELISA,and the correlations with HCV RNA,and HCV antibody detection.Results From patients infected with hepatitis C to the end of treatment,HCV antibody tests results were all positive,but HCV-RNA detection and HCV total antigen test results would change with the fluctuations in the treatment regimen,that is,with the pathogenesis.We tested 189 samples (the total samples of the 40 patients in different period of onset),there were 51 positive samples of the HCV RNA detection results,and there were 44 positive of the 51 samples by HCV total antigen detection,the positive rate was 86.27％.There were 138 negative samples by HCV-RNA detection results,and the HCV total antigen results showed 3 positive samples.There was no significant differences (x2 =1.6,P ＞ 0.05).Conclusion HCV antigen detection may help the diagnosis and treatment of chronic hepatitis C patients,especially in monitoring the course of the disease hepatitis C.It could be used as the substitution of the HCV-RNA detection in the medium hospitals thta are lack of RT-PCR detection.关键词
丙型肝炎病毒/HCV总抗原/丙型肝炎病毒核酸/病程Key words
hepatitis C virus / HCV total antigen/ hepatitis C virus nucleic acid/ pathogenesis分类
医药卫生引用本文复制引用
李洪臣,周见远,周咏武,欧兰香,胡道奇,李莉,张纵,谭德明,刘洪波..丙型肝炎病毒总抗原检测用于病程监测的研究[J].中国输血杂志,2013,26(5):443-445,3.
