中国实验动物学报2013，Vol.21Issue(3)：16-20,5.DOI:10.3969/j.issn.1005-4847.2013.03.004
镉染毒对雄性大鼠骨生物力学性能的影响
Effects of cadmium on bone biomechanical properties in male rats
摘要
Abstract
Objective To investigate the effects of cadmium (Cd) on biomechanical properties of femur and lumbar spine in male rats.Methods Twenty-four 8-week-old Sprague-Dawley male rats were randomly divided into 4 groups:one control group which were given CdCl2 by subcutaneous injection at a doses of 0 (sodium chloride) and three experimental groups which were given 0.1,0.5 and 1.5 mg Cd/kg body weight,respectively.At the 12th week,blood,lumbar spine and femur were collected for cadmium assay,bone mineral density (BMD) measurement and biomechanical test.Results The Cd content in blood and bone of rats treated with Cd was significantly higher than that in the control (P ＜0.05).BMD of rats exposed to 0.5mg/kg bw and 1.5mg/kg·bw were significantly lower than the control(P ＜0.05).Biomechanical properties of the femur and lumbar spine in rats treated with Cd were decreased compared with the control,especially for biomechanical properties of femur in the 1.5mg/kg· bw group and biomechanical properties of the lumbar spine in the 0.5 and 1.5mg/kg· bw groups (P ＜ 0.01).Conclusion Cd exposure reduces bone biomechanical properties and the reduction of biomechanics of lumbar spine is more sensitive than those of the femur.关键词
镉/大鼠/骨密度/生物力学Key words
Cadmium/ Rat/ Bone mineral density/ Bone biomechanical property分类
生物科学引用本文复制引用
秦波音,陈晓,朱国英,周晓辉,周文江..镉染毒对雄性大鼠骨生物力学性能的影响[J].中国实验动物学报,2013,21(3):16-20,5.基金项目
国家自然科学基金青年基金资助项目(编号:81102148). （编号:81102148）
