中国比较医学杂志2013，Vol.23Issue(6)：71-74,4.DOI:10.3969.j.issn.1671.7856.2013.006.016
Tau蛋白高度磷酸化致阿尔茨海默病动物模型研究进展
Advances in research of animal models of Alzheimer's disease induced by hyperphosphorylated tau
摘要
Abstract
Alzheimer's disease (AD) is a progressive and fatal neurodegenerative disorder.The aggregation of hyperphosphorylated tau into neurofibrillary tangles (NFT) is a hallmark in the histopathology of AD.A number of mouse models have been created to study the major neuropathological mechanism and the drug research.We provide here some considerations for selecting a mouse model of AD,including tau transgenic mice,hyperphosphorylated tau animal model induced by imbalance of the activities of kinases and phosphatases,and animal model of hyperphosphorylated tau induced by decreasing O-GlcNAcylation.关键词
Tau蛋白磷酸化/阿尔茨海默病/模型,动物Key words
Hyperphosphorylated tau, Alzheimer's disease, Animal model分类
医药卫生引用本文复制引用
杨翠翠,李林,张兰..Tau蛋白高度磷酸化致阿尔茨海默病动物模型研究进展[J].中国比较医学杂志,2013,23(6):71-74,4.基金项目
国家自然科学基金(No.81274120),北京市自然科学基金(No.7132110),首都卫生发展科研专项(No.2011-1001-05)北京市中医管理局重点项目(No.KJTS2011-04),北京市新世纪百千万人才工程项目(No.008-0014). （No.81274120）
