中国药房2013，Vol.24Issue(21)：1945-1947,3.DOI:10.6039/j.issn.1001-0408.2013.21.09
新型药物载体七元瓜环的一般药理学实验研究
Study on General Pharmacological Effects of New Drug Carrier Cururbit[7]uril
摘要
Abstract
OBJECTIVE:To investigate the influence of new drug carrier cururbit[7]uril (Q7) on central nervous system of mice and cardiovascular system and respiratory system of rats.METHODS:The autonomic activities,pain,hour of sleep,the number of mice falling asleep and convulsions of mice were investigated in blank control (water) group,Q7 high-dose,medium-dose and low-dose groups (1.404,0.702,0.351 g/kg) after medication (n=12); the changes of body temperature,cardiovascular system and respiration system in rats were investigated in normal control group,Q7 high-dose,medium-dose and low-dose groups (0.982,0.491,0.246 g/kg) after medication (n=6).RESULTS:Compared with blank control group,there was no significant difference in autonomic activities,pain,hour of sleep,the number of mice falling asleep and convulsions of mice in Q7 groups (P＞0.05) ; compared with normal control group,the body temperature,the frequency and depth of respiration,heart rate,diastolic blood pressure,arterial pressure,PR,QRS,QT and T-wave had no significant changes in Q7 groups (P＞0.05).CONCLUSIONS:Q7 has no significant effects on the central nervous system of mice,neither on cardiovascular system or respiratory system of rats.关键词
七元瓜环/一般药理学/中枢神经系统/呼吸系统/心血管系统/小鼠/大鼠Key words
Cururbit[7]uril/ General pharmacology/ Central nervous system/ Respiratory system/ Cardiovascular system/ Mice/ Rats分类
医药卫生引用本文复制引用
杨长福,刘明,徐剑,张永萍..新型药物载体七元瓜环的一般药理学实验研究[J].中国药房,2013,24(21):1945-1947,3.基金项目
贵州省中药现代化科技产业研究开发专项资助项目(No.黔科合中药字[2009]5035号) （No.黔科合中药字[2009]5035号）
