中国药房2013，Vol.24Issue(22)：2049-2050,2.DOI:10.6039/j.issn.1001-0408.2013.22.12
基于孕烷X受体基因多态性指导肾移植受者他克莫司的个体化用药
Guidance for Individual Administration of Tacrolimus in Kidney-transplanted Patients According to Pregnane X Receptor Genetic Polymorphism
摘要
Abstract
OBJECTIVE:To study the relationship between pregnane X receptor (PXR-C24381A) genetic polymorphism and dosage of tacrolimus (FK506) in kidney-transplanted patients.METHODS:The PXR genotypes of 60 kidney-transplanted patients were determined by PCR-direct sequencing.Blood concentration of FK506 was measured by ELISA.The blood concentration of FK506 in patients with different genotypes was compared with dosage (C/D ratio).RESULTS:The frequency of PXR-C24381A allele C was 75％,and that of allele A was 25％.C/D ratio of patients with A/A genotype was significantly lower than those with C/A genotype or C/C genotype (P＜0.05).CONCLUSIONS:PXR-C24381A polymorphism is correlated with the blood concentration of FK506 in kidney-transplanted patients.If the same blood concentration of FK506 is presented in three genotypes,patients with A/A genotype should take higher dosage than those with C/C and C/A genotypes.关键词
他克莫司/基因多态性/血药浓度/剂量Key words
Tacrolimus/ Genetic polymorphism/ Blood concentration/ Dosage分类
医药卫生引用本文复制引用
王金平,李澎灏,李雯,李璐..基于孕烷X受体基因多态性指导肾移植受者他克莫司的个体化用药[J].中国药房,2013,24(22):2049-2050,2.基金项目
深圳市科技计划资助项目(No.201203053) （No.201203053）
