中国药房2013，Vol.24Issue(22)：2065-2067,3.DOI:10.6039/j.issn.1001-0408.2013.22.18
盐酸莫西沙星氯化钠注射液治疗下呼吸道感染的药动学和药效学研究
Pharmacokinetics and Pharmacodynamics of Moxifloxacin in the Treatment of Lower Respiratory Tract Infection
朱文静 1王少华 2张淑立 2赵艳 2张文竹 2孙韬华2
作者信息
- 1. 大连医科大学药学院,辽宁大连116044
- 2. 青岛市市立医院,山东青岛 266011
- 折叠
摘要
Abstract
OBJECTIVE:To study the pharmacokinetics,clinical and bacteriological efficacies of moxifloxacin in the treatment of lower respiratory tract infection.METHODS:18 cases of lower respiratory tract infection were collected and treated with moxifloxacin 400 mg/d intravenously.The blood concentration of moxifloxacin was determined by HPLC.Both clinical and bacteriological efficacies were both recorded.The sputum specimens collected before and after the therapy were cultured to measure the MIC by broth dilution method.RESULTS:The peak concentration,trough concentration and steady state blood concentration of moxifloxacin reached (3.69 ± 0.05)mg/L,(1.43 ± 0.10)mg/L and (4.25 ± 0.06)mg/L,respectively.Among 18 cases of lower respiratory tract infection treated with Moxifloxacin sodium chloride injection,15 cases were cured,1 case was significantly effective and 2 cases improved.The total effective rate was 88.89％.Most of the clinical symptoms and signs improved obviously after 3 days.Bacteria clearance was 88.89％.CONCLUSIONS:Treating lower respiratory tract infection,Moxifloxacin sodium chloride injection can achieve effective therapeutic concentration and get good curative effect.关键词
莫西沙星/下呼吸道感染/药动学/药效学Key words
Moxifloxacin/ Lower respiratory infection/ Pharmacokinetics/ Pharmacodynamics分类
医药卫生引用本文复制引用
朱文静,王少华,张淑立,赵艳,张文竹,孙韬华..盐酸莫西沙星氯化钠注射液治疗下呼吸道感染的药动学和药效学研究[J].中国药房,2013,24(22):2065-2067,3.
