中国药房2013，Vol.24Issue(22)：2073-2075,3.DOI:10.6039/j.issn.1001-0408.2013.22.21
注射用硫普罗宁与不同输液溶媒配伍的稳定性考察
Study on the Compatible Stability of Tiopronin for Injection in Different Infusion Solvents
刘家宝 1朱立勤2
作者信息
- 1. 天津医科大学,天津300070
- 2. 天津市南开医院,天津市300100
- 折叠
摘要
Abstract
OBJECTIVE:To study the stability of Tiopronin for injection in different infusion solvents.METHODS:After dissolved in special solvent (5％ sodium bicarbonate,pH 7.5-8.5),the changes in appearance,insoluble particles and pH of Tiopronin for injection in 5％ Glucose injection and 0.9％ sodium chloride injection at 20 ℃ for 12 h were observed or tested; the contents of tiopronin in infusion solvents were measured by HPLC at various test time.RESULTS:Tiopronin for injection prepared according to the instruction after the expansion,its appearance and the number of insoluble particles had no significant changes,pH value was gradually increased while their contents were significantly decreased in 12 h at 20 ℃.CONCLUSIONS:Tiopronin for injection prepared by special solvents should be used up as soon as possible for the stability of quality.关键词
注射用硫普罗宁/专用溶媒/5％葡萄糖注射液/0.9％氯化钠注射液/配伍稳定性Key words
Tiopronin for injection/ Special solvent/ 5％ Glucose injection/ 0.9％ Sodium chloride injection/ Compatible stability分类
医药卫生引用本文复制引用
刘家宝,朱立勤..注射用硫普罗宁与不同输液溶媒配伍的稳定性考察[J].中国药房,2013,24(22):2073-2075,3.
