中国药房2013，Vol.24Issue(22)：2075-2077,3.DOI:10.6039/j.issn.1001-0408.2013.22.22
卡培他滨同步三维适形放疗治疗老年食管癌根治术后局部复发的临床观察
Clinical Observation of Capecitabine Combined with 3D-CRT for Local Recurrence in the Elderly Patients after Esophageal Cancer Radical Surgery
张学苗 1薛惠 1邵艳萍1
作者信息
- 1. 德州市中医院肿瘤内科,山东德州253013
- 折叠
摘要
Abstract
OBJECTIVE:To observe the therapeutic effect and safety of capecitabine combined with 3D-CRT in the treatment of local recurrence in elderly patients after esophageal cancer radical surgery.METHODS:By retrospective study,62 patients were randomly assigned into treatment group (capecitabine combined with 3D-CRT) and control group (3D-CRT) with 31 cases in each group.Patients in treatment group were given capeeitabine 1 000 mg/m2,bid,po,half an hour after dinner,d1-14,21 days for a course.Therapeutic efficacy,adverse drug reaction and long-term efficacy were analyzed and compared after two courses.RESULTS:The effective rates of treatment group and control group were 83.87％ and 54.84％ (P＜0.05) ; the incidence of gastrointestinal reaction were 48.39％ and 25.81％ (P＜0.05); those of grade Ⅰ-Ⅱ bone marrow inhibition were 35.48％ and 22.58％ (P＜0.05); 1 year local control rate were 70.97％ and 45.16％ (P＜0.05).CONCLUSIONS:Capecitabine combined with 3D-CRT has an exact curative effect on local recurrence in the elderly patients after esophageal cancer radical surgery,and the side effects are increasing but can be tolerated.关键词
卡培他滨/同步三维适形放疗/老年/食管癌/根治术后/局部复发Key words
Capecitabine/ Combined with 3D-CRT/ Elderly/ Esophageal cancer/ After radical surgery/ Local recurrence分类
医药卫生引用本文复制引用
张学苗,薛惠,邵艳萍..卡培他滨同步三维适形放疗治疗老年食管癌根治术后局部复发的临床观察[J].中国药房,2013,24(22):2075-2077,3.
