中国药房2013，Vol.24Issue(23)：2133-2135,3.DOI:10.6039/j.issn.1001-0408.2013.23.08
尿毒清颗粒对糖尿病肾病模型大鼠肾组织的保护作用研究
Protective Effect of Niaoduqing Granules on Renal Tissue in Diabetic Nephropathy Model Rats
摘要
Abstract
OBJECTIVE:To study the protective effect of Niaoduqing granules on renal tissue in diabetic nephropathy (DN)rats.METHODS:DN model was established by intraperitoneal injection of streptozotocin (60 mg/kg).Model rats were divided into 3 groups,i.e.blank group (constant volume of normal saline),model group (constant volume of normal saline) and Niaoduqing granules group (40 mg/kg).They were given medicine intragastrically once a day for consecutive 8 weeks.The body weight,renal weight,renal weight/body weight index,blood glucose,BUN,Ccr and blood β2 microglobulin were determined.The morphological changes of renal tissue were observed with slice.RESULTS:Compared with blank group,renal weight,renal weight/body weight index,blood glucose,Bun,Ccr and blood β2 microglobulin were increased significantly in model group(P＜0.01 or P＜0.05).Pathological changes of renal tissue were observed,such as glomerular basement membrane thickening and mesangial cells proliferation.Compared with model group,renal weight,renal weight/body weight index,blood glucose,BUN,Ccr and blood β2 microglobulin of Niaoduqing granules group decreased significantly(P＜0.01 or P＜0.05) ; the pathological changes of kidney tissues were relieved to some extent.CONCLUSIONS:Niaoduqing granules may play a protective role against glomerular hypertrophy and sclerosis so as to down-regulate renal function reduction of DN model rats.关键词
尿毒清颗粒/肾组织/糖尿病肾病Key words
Niaoduqing granules/ Renal tissue/ Diabetic nephropathy分类
医药卫生引用本文复制引用
王玉浔,安雅臣,赵晓晶,史国辉..尿毒清颗粒对糖尿病肾病模型大鼠肾组织的保护作用研究[J].中国药房,2013,24(23):2133-2135,3.基金项目
河北联合大学附属医院博硕科研基金资助项目(No.BS05009) （No.BS05009）
