中国药房2013，Vol.24Issue(23)：2141-2144,4.DOI:10.6039/j.issn.1001-0408.2013.23.11
三七三醇皂苷微丸的处方优化及制备工艺研究
Optimization of the Formula and Preparation Technology Study of Panaxatriol Saponins Pellets
摘要
Abstract
OBJECTIVE:To study the formula and preparation technology of Panaxatriol saponins pellets.METHODS:The formula Panaxatriol saponins pellets,preparation technology parameters of extrusion-spheronization and fluid bed coating technology were optimized with single factor test,using forming characteristics and physical parameters as indicators.RESULTS:Optimized formula was as follows:panaxatriol saponins 120 g,cellulose microcrystalline cellulose 90 g,starch 90g,PVP K30 6.0 g,50％ethanol solution containing 8％ PVP K30 as adhensive agent; The pellets prepared by fluid bed coating technology were all spheral completely with appropriate hardness and uniform particle size distribution; the yield of the pellet was not less than 93％.CONCLUSIONS:The fluid bed coating technology is simple and fesiable,prepared pellets were excellent in quality and suitable for further enteric coating.关键词
三七三醇皂苷/微丸/挤出滚圆法/流化床法Key words
Panaxatriol saponins/ Pellets/ Extrusion-spheronization method/ Fluid bed method分类
医药卫生引用本文复制引用
冷静,林大胜,杨华蓉,万方,曹科,王莉..三七三醇皂苷微丸的处方优化及制备工艺研究[J].中国药房,2013,24(23):2141-2144,4.基金项目
国家"十一五"科技支撑计划资助项目(No.2006BAI11B04) （No.2006BAI11B04）
重庆市卫生局中医药科研计划资助项目(No.2010-2-150) （No.2010-2-150）
