中国药房2013，Vol.24Issue(23)：2164-2167,4.DOI:10.6039/j.issn.1001-0408.2013.23.18
麒麟丸质量标准的提高研究
Study on the Improvement of Quality Standard for Kirin Pill
摘要
Abstract
OBJECTIVE:To improve the quality standard of Kirin pill.METHODS:Salvia miltiorrhiza,Citrus reticulata,Lycium barbarum and Cynomorium songaricum in this prescripition were identified by TLC.The concent of stilene glucoside in Polygonum multiflorum was determined by HPLC.The determination was performed on Kromasil 100-5 C18(250 mm×4.6 mm,5 μm) column with mobile phase consisted of acotonitrile-water(15∶85,V/V)at the flow rate of 1.0 ml/min.The column temperature was maintained at 25 ℃,and detection wavelength was set at 320 nm.RESULTS:TLC spots were clear and well-separated without interfence from negative sample.The linear range of stilene glucoside were 0.040 04-0.600 60 μg(r=0.999 9) with an average recovery of 96.40％ (RSD=0.93％,n=6).The RSDs of precision,stability and reproducibility tests were all lower than 2 ％.CONCLUSIONS:Established standard is suitable for the quality control of Kirin pill.关键词
麒麟丸/质量标准/提高/薄层色谱法/高效液相色谱法/二苯乙烯苷/锁阳/枸杞子Key words
Kirin pill/ Quality standard/ Improvement/ TLC/ HPLC/ Stilene glucoside/ Cynomorium songaricum/ Lycium barbarum分类
医药卫生引用本文复制引用
陈小凯,段启,何伟,李勇,朱怡洁,庄义修..麒麟丸质量标准的提高研究[J].中国药房,2013,24(23):2164-2167,4.基金项目
广东省建设中医药强省立项资助科研课题(No.20121108) （No.20121108）
