中国药房2013，Vol.24Issue(24)：2238-2240,3.DOI:10.6039/j.issn.1001-0408.2013.24.09
结构脂肪乳与中/长链脂肪乳对危重症患者肝功能和血脂的影响比较
Comparison of the Effects of Structured Triglyceride and Medium/Long Chain Triglycerides on Liver Function and Serum Lipid in Critical Patients
摘要
Abstract
OBJECTIVE:To compare the effects of structured triglyceride (STG) and medium/long chain triglycerides (MCT/ LCT) on liver function and serum lipid in critical patients.METHODS:80 critical patients were randomized into study group and control group.Both groups were given parenteral nutrition support,50％ Glucose injection 300 ml,Compound amino acid injection 500 ml,trace elements,insulin,vitamin,electrolyte,etc.Study group was additionally given 20％ STG injection 250 ml.Control group was additionally given 20％ MCT/LCT injection 250 ml.They were injected with relevant medicines within 16-18 h/d for 10 days.The liver function and serum lipid in critical patients of 2 groups were detected,and the occurrence of ADR was observed.RESULTS:Liver function of both groups had no significant change after medication,and was in the normal range.The triglyceride and cholesterol didn't obviously elevate in study group after giving STG injection,but the triglyceride and cholesterol obviously elevated in control group after giving MCT/LCT injection:there was statistical significance between 2 groups(P＜0.05).The incidence of ADR had no statistical significance between 2 groups (P＞0.05).CONCLUSIONS:Both two lipid emulsions are safe and effective in parenteral nutrition support for critical patients.But serum lipid have elevated after using MCT/LCT,if those patients have metabolic disorder originally.So,we prefer to select STG for those patients.关键词
结构脂肪乳/中/长链脂肪乳/危重症患者/肝功能/血脂/影响Key words
Structured triglyceride/Medium/long chain triglyceride/Critical patients/Liver function/Serum lipid/Effect分类
医药卫生引用本文复制引用
陈辉珍,蔡玲,章昕..结构脂肪乳与中/长链脂肪乳对危重症患者肝功能和血脂的影响比较[J].中国药房,2013,24(24):2238-2240,3.
