中国药房2013，Vol.24Issue(24)：2250-2252,3.DOI:10.6039/j.issn.1001-0408.2013.24.14
硒联合比索洛尔治疗自身免疫性甲状腺疾病合并阵发性房颤的临床观察
Clinical Observation of Selenium Combined with Bisoprol in the Treatment of Autoimmune Thyroid Disease (AITD) Complicating with Paroxysmal Atrial Fibrillation
摘要
Abstract
OBJECTIVE:To observe clinical efficacy of selenium combined with bisoprol in the treatment of autoimmune thyroid disease (AITD) complicating with paroxysmal atrial fibrillation.METHODS:42 patients with AITD complicating with paroxysmal atrial fibrillation were randomized into trial group (24 cases) and control group (18 cases).On the basis of warfarin treatment,trial group received selenium combined with bisoprol,and control group was given counterpart dose of placebo.The levels of FT3,FT4,TSH,TGAb and TPOAb were determined by electrochemiluminescence immunoassay after 6 months of treatment.24 h dynamic electrocardiograms were applied to measure the function of heart,and ADR of patients were recorded.RESULTS:After 6 months of combination treatment,the index of control group had no significant change in control group compared to before treatment (P＞0.05) ; compared with control group and before treatment,the levels of FT3 and FT4 in experiment group had no significant change (P＞0.05); TSH level increased significantly (P＜0.05),while TGAb and TPOAb decreased significantly (P＜0.05); heart rate of patients decreased significantly compared to before treatment,and 75％ patients with atrial fibrillation were corrected.Left ventricular diastolic function of heart improved obviously.No significant ADR was found in 2 groups.CONCLU-SIONS:Selenium combined with bisoprol in the treatment of AITD complicating with paroxysmal atrial fibrillation can improve TSH,TGAb and TPOAb levels and left ventricular function with sound safety.关键词
硒/比索洛尔/自身免疫性甲状腺疾病/阵发性房颤Key words
Selenium/Bisoprol/Autoimmune thyroid disease/Paroxysmal atrial fibrillation分类
医药卫生引用本文复制引用
郑亿,王玉华,杨姣..硒联合比索洛尔治疗自身免疫性甲状腺疾病合并阵发性房颤的临床观察[J].中国药房,2013,24(24):2250-2252,3.
