摘要
Abstract
OBJECTIVE:To study the protective effects of phloroglucinol (Phlo) on cardiac tissue in heart failure model rats.METHODS:Rats were randomly divided into blank control group,model group and Phlo group [30 mg/(kg· d)] with 15 rats in each group.Heart failure model was induced by aorta thoracica constriction in the latter 2 groups.The hemodynamic parameters of left ventricular [MAP,heart rate,LVEDP,LVSP and the maximal change rate of left intraventricular pressure (± dp/dtmax)],cardiomyocyte diameter,plasma biochemical markers [B type natriuretic peptide (BNP),cardiac troponin (cTnI)],oxidative stress [MDA,SOD and oxygen free radicals] and inward and outward rectifier potassium current (IK1、Ito) were all observed in rats after intragastric administration of Phlo for 12 consecutive weeks.RESULTS:Compared with blank control group,model was induced in model group successfully; compared with model group,LVSP,± dp/dtmax,IK1、Ito,MDA and SOD contents of Phlo group increased significantly (P＜0.05),while LVEDP,cardiomyocyte diameters,BNP,cTnI and oxygen free radical were decreased significantly (P＜ 0.05); but there was no significant different with blank control group.CONCLUSIONS:Phlo can effectively reverse the cardiac hypertrophy and enhance IK1 and Ito in heart failure rats,associating with possible mechanisms to reduce oxidative stress.关键词
间苯三酚/心力衰竭/大鼠/心肌肥大/内向整流钾电流/外向整流钾电流Key words
Phloroglucinol/ Heart failure/ Rats/ Myocardial hypertrophy/ Inward rectifier potassium current/ Outward rectifier potassium current分类
医药卫生
