摘要
Abstract
OBJECTIVE:To study the equilibrium solubility and the apparent oil-water partition coefficient of vitacoxib in different medium.METHODS:The equilibrium solubility of vitacoxib in 0.1 mol/L hydrochloric acid,PBS solution (pH 2.0,5.8,6.8,7.4),water,0.5％ sodium dodecyl sulfate solution and 0.5％ Polysorbate 80 solution at 37 ℃ were determined by HPLC and saturation method.The apparent oil-water partition coefficient was calculated with concentration ratio of vitacoxib in oil phase (n-octanol) and water phase after partition equilibrium.RESULTS:The equilibrium solubility of vitacoxib were 6.62,8.66,6.65,14.41,27.38,55.65,96.17 and 18.37 μg/ml; and the lgP of apparent oil-water partition coefficient of vitacoxib were 0.45,0.61,0.43,0.40,0.44,0.47,0.35 and 0.21,respectively.CONCLUSIONS:Vitacoxib is a lipophilic drug,and the solubility of vitacoxib in water is poor.The solubility of vitacoxib in 0.5％ sodium dodecyl sulfate solution is the largest,which indicates that in vivo absorption of vitacoxib is not good.关键词
维他昔布/表观油水分配系数/平衡溶解度/高效液相色谱法Key words
Vitacoxib/ Apparent oil-water partition coeficient/ Equilibrium solubility/ HPLC分类
医药卫生
