中国药房2013，Vol.24Issue(25)：2380-2382,3.DOI:10.6039/j.issn.1001-0408.2013.25.28
β-环糊精/离子液体/毛细管电泳法拆分3种手性药物
Separation of 3 Kinds of Chiral Drugs by β-CD/Ionic Liquid/Capillary Electrophoresis
摘要
Abstract
OBJECTIVE:To establish the method for the separation of 3 kinds of chiral drugs,i.g.chlorphenamine,terbutaline and dioxopromethazine.METHODS:Using β-cyclodextrin (β-CD) and chiral ionic liquid 1-butyl-2,3-dimethylimidazole tetrafluoroborate (IL) as chiral selectors,3 kinds of chiral drugs were separated by capillary electrophoresis.The effects of the concentrations of IL and β-CD,pH of NaH2PO4 buffer and voltage on enantiometric separation were investigated.RESULTS:The optimal condition was as follows:β-CD of 10.0 mmol/L,IL of 20.0 mmol/L,pH of 2.5,voltage of 20 kV.Under this condition,chlorphenamine,terbutaline and dioxopromethazine enantiomers were separated to the highest degree,with separation rate of 3.2,1.9 and 1.8.CONCLUSIONS:Established β-CD/IL/capillary electrophoresis provides a new method for the separation of chiral drugs.关键词
手性药物/离子液体/β-环糊精/对映体拆分/毛细管电泳法Key words
Chiral drugs/ Ionic liquid/ β-cyclodextrin/ Enantiometric separation/ Capillary electrophoresis分类
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李云,赵胜芳,崔瑞杰,娄素琴..β-环糊精/离子液体/毛细管电泳法拆分3种手性药物[J].中国药房,2013,24(25):2380-2382,3.
